Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modelling.

Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better represents the prolonged and pronounced inflammation observed in conditions like sepsis. Yet very few experimental studies have administered endotoxin using both strategies, leaving significant gaps in determining the underlying mechanisms responsible for their differing immune responses.

Matrix and agent-based modeling of threats to a diamond-backed terrapin population.

Population models are important tools for evaluating human impacts and potential management approaches on declining species. However, often studies are limited by constraints of the specific modeling approach. In this study we considered the persistence of a diamond-backed terrapin (Malaclemys terrapin) population using two distinct modeling approaches.