Publications by authors named "Kristen Victor"
Microbial transformation of bile acids affects intestinal immune homoeostasis but its impact on inflammatory pathologies remains largely unknown. Using a mouse model of graft-versus-host disease (GVHD), we found that T cell-driven inflammation decreased the abundance of microbiome-encoded bile salt hydrolase (BSH) genes and reduced the levels of unconjugated and microbe-derived bile acids. Several microbe-derived bile acids attenuated farnesoid X receptor (FXR) activation, suggesting that loss of these metabolites during inflammation may increase FXR activity and exacerbate the course of disease.
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- The study aimed to create a model to understand how concurrent chemoradiation therapy (CCRT) for oropharyngeal cancer affects tongue function and structure, as current research methods are lacking.
- Twenty-one male rata were divided into three groups to assess tongue strength and muscle changes after receiving CCRT or no treatment; results were collected at 2 weeks and 5 months.
- Findings showed significant decreases in tongue strength and movement after CCRT, but no observable changes in muscle collagen content, indicating other factors might be responsible for the dysfunction observed.