Publications by authors named "Kristen Read"
Biochem Pharmacol
April 2023
Article Synopsis
- Monoclonal antibodies (mAbs) are a rapidly growing class of drugs used for treating diseases like cancer and autoimmune disorders, but studying their dosage and efficacy traditionally involves costly and ethically challenging non-human primates.
- Rodent models better mimicking human pharmacokinetics are being developed, but standard mice do not accurately reflect the binding of human antibodies due to differences in the FCRN receptor.
- The newly created SYNB-hFCRN mice utilize CRISPR/Cas9 technology to accurately express the human FCRN in mice, providing a more reliable model for preclinical pharmacokinetics studies important for early drug development.
