Publications by authors named "Kristen Mead"
Article Synopsis
- This study aims to analyze the genetic backgrounds and resistance traits of common pneumococcal serotypes in Canada over the past five years, focusing on their behavior after the introduction of the PCV13 vaccine.
- Researchers sequenced the genomes of a sample from the ten most prevalent serotypes and used this data to identify important characteristics, including virulence and antimicrobial resistance (AMR) genes.
- The results revealed significant changes in the prevalence of certain serotypes, with some increasing in numbers and one, 19A, decreasing, highlighting the need for ongoing surveillance to track new bacterial lineages and AMR development in Canada.
Article Synopsis
- - The study analyzed the molecular epidemiology of invasive meningococcal disease (IMD) in Atlantic Canada from 2014 to 2020, specifically looking at serotype and potential vaccine coverage for serogroup B (MenB).
- - Results revealed a variety of strains, with MenB being the most common (42 out of 56 isolates), and distinct geographical distributions of certain clones in Newfoundland and Labrador versus New Brunswick and Nova Scotia.
- - Vaccine predictions indicated that 54.8% of MenB strains were likely covered by the MenB vaccine Bexsero, while a high percentage (95.3%) could be covered by Trumenba, highlighting the importance of ongoing surveillance in IMD. *
Background: Invasive pneumococcal disease (IPD), which is caused by , has been a nationally notifiable disease in Canada since 2000. The use of conjugate vaccines has markedly decreased the incidence of IPD in Canada; however, the distribution of serotypes has shifted in favour of non-vaccine types. This report summarizes the demographics, serotypes and antimicrobial resistance of IPD infections in Canada in 2020.
View Article and Find Full Text PDFInvasive group A streptococcal disease surveillance in Canada, 2020.
Can Commun Dis Rep
September 2022
Background: Invasive group A streptococcal (iGAS) disease (caused by ) has been a nationally notifiable disease in Canada since 2000. This report summarizes the demographics, types and antimicrobial resistance of iGAS infections in Canada in 2020.
Methods: The Public Health Agency of Canada's National Microbiology Laboratory (Winnipeg, Manitoba) collaborates with provincial and territorial public health laboratories to conduct national surveillance of invasive typing was performed on all isolates using the Centers for Disease Control and Prevention sequencing protocol.
Antimicrobial resistance in Streptococcus pneumoniae represents a threat to public health, and monitoring the dissemination of resistant strains is essential to guiding health policy. Multiple-variable linear regression modeling was used to determine the contributions of molecular antimicrobial resistance determinants to antimicrobial MICs for penicillin, ceftriaxone, erythromycin, clarithromycin, clindamycin, levofloxacin, and trimethoprim-sulfamethoxazole. Training data sets consisting of Canadian S.
View Article and Find Full Text PDFThe rare sugar 2,6-dideoxy-2-acetamidino-L-galactose (L-FucNAm) is found only in bacteria and is a component of cell surface glycans in a number of pathogenic species, including the O antigens of Pseudomonas aeruginosa serotype O12 and Escherichia coli O145. P. aeruginosa is an important opportunistic pathogen, and the O12 serotype is associated with multidrug-resistant epidemic outbreaks.
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