Publications by authors named "Kristen L Rychalsky"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can cause gastrointestinal (GI) inflammatory side effects, known as immune-related adverse events (irAEs), which are typically treated with steroids, but some cases do not respond.
- This study analyzed the effectiveness of second-line treatments, like infliximab, vedolizumab, and adalimumab, in patients with steroid-refractory GI irAEs from 2011 to 2019.
- Findings show that most patients (89.7%) responded positively to these treatments, with an even higher resolution rate (94.4%) in those who started infliximab within 14 days of steroid treatment, typically resolving symptoms within about 17 days.
Tremor is a cardinal symptom of parkinsonism, occurring early on in the disease course and affecting more than 70% of patients. Parkinsonian resting tremor occurs in a frequency range of 3-7 Hz and can be resistant to available pharmacotherapy. Despite its prevalence, and the significant decrease in quality of life associated with it, the pathophysiology of parkinsonian tremor is poorly understood.
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