-Transgenic BALB/c Mice as a Model of Pseudomonas aeruginosa Infections of the Cystic Fibrosis Lung.

The opportunistic pathogen is responsible for much of the morbidity and mortality associated with cystic fibrosis (CF), a condition that predisposes patients to chronic lung infections. lung infections are difficult to treat because adapts to the CF lung, can develop multidrug resistance, and can form biofilms. Despite the clinical significance of , modeling infections in CF has been challenging.

Clearance of Staphylococcus aureus from Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens.

is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-embedded bacterial populations. However, the addition of antibiotics was required to eradicate remaining planktonic populations.