Publications by authors named "Kristen H Scherrer"
The macrocyclic tetrapeptide CJ-15,208 ([Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated the effects of substitution of Trp and D-Trp on the peptides' opioid activity, antinociceptive tolerance, and the ability to prevent relapse to extinguished drug-CPP. Six analogs were synthesized using a combination of solid-phase peptide synthesis and cyclization in solution.
View Article and Find Full Text PDFBody maps are commonly used to capture the location of a patient's pain and thus reflect the extent of pain throughout the body. With increasing electronic capture body map information, there is an emerging need for clinic- and research-ready tools capable of visualizing this data on individual and mass scales. Here we propose CHOIRBM, an extensible and modular R package and companion web application built on the grammar of graphics system.
View Article and Find Full Text PDFArticle Synopsis
- The study developed an electronic body map called the Collaborative Health Outcomes Information Registry (CHOIR) body map to improve the identification of pain in patients with chronic pain.
- Using a Delphi technique for validation, the study compared responses from 530 chronic pain participants and found that the CHOIR body map had a high reliability score, indicating consistent results over time.
- Despite high correlation between the body map and questionnaire responses, some discrepancies were noted in pain areas like the back and shoulders, which were addressed through improved instructions for participants.
Introduction: Complex Regional Pain Syndrome (CRPS), a rare and severe chronic pain condition, often responds poorly to existing treatments. Previous studies demonstrated Transcranial Magnetic Stimulation (TMS) provided short-term pain relief for upper extremity CRPS.
Methods: Building on previous methodologies, we employed a TMS protocol that may lead to significant pain relief for upper and lower extremity CRPS in a nonrandomized open label pilot trial involving 21 participants.