Publications by authors named "Kristen Cofer"
Int J Mol Sci
October 2024
Article Synopsis
- - Environmental heat stress is a major concern for warfighters, athletes, and workers, leading to exertional heat illness (EHI) that can cause severe health issues and long-term problems like cardiovascular dysfunction.
- - A study invested genetic factors related to EHI by using whole-exome sequencing on 53 cases, finding that 30.2% of participants had clinically significant gene variants across 14 different genes, some of which are linked to muscle disorders and thermoregulation.
- - Notably, the p.Arg905Trp variant was identified to hinder the thermal sensitivity of the TRPM4 channel, suggesting a new molecular mechanism of susceptibility to EHI, and highlighting the complexity of its genetic causes.
