Rapid Resolution of Perianal Crohn's Disease with Upadacitinib.

A 20-year-old woman with ileocolonic, stricturing, and penetrating Crohn's disease (CD) presented with new onset perianal and vulvar CD despite having a diverting ileostomy and medical therapy with ustekinumab. She had previous secondary nonresponse to infliximab, vedolizumab, and adalimumab. There is a paucity of data supporting the use of medical therapies for perianal CD.

Elevated dietary selenium rescues mitochondrial capacity impairment induced by decreased vitamin E intake in young exercising horses.

Maintenance of mitochondrial health, which is supported in part by dietary antioxidants such as selenium (Se) and vitamin E (vitE), is pertinent to optimizing athletic performance. Deficiencies in Se and vitE negatively impact muscle health but mitochondrial adaptations to various levels of dietary Se and vitE are poorly understood. Young Quarter Horses (mean ± SD: 17.

Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle.

Stress negatively affects the gastrointestinal tract (GIT) barrier function, resulting in compromised animal health. A deeper understanding of how diet and stress impacts the GIT barrier function in feedlot cattle is needed. Aspirin decreases mucus production and mucosal repair in the GIT and could be used as a model for GIT barrier dysfunction research.

Effect of a hydrolyzed mannan- and glucan-rich yeast fraction on performance and health status of newly received feedlot cattle1.

A 2-part experiment was conducted to determine the effects of a blend of specialized mannan- and glucan-rich fractions of yeast (Select-TC, Alltech Inc.) on the health status and performance of steers during the first 2 mo of the feedlot period. Eighty crossbred steers were acquired from commercial sale barns in Mississippi and Georgia and transported to Purdue University.

Skeletal muscle and liver gene expression profiles in finishing steers supplemented with Amaize.

Our main objective was to evaluate the effects of feeding α-amylase (Amaize, Alltech Inc., Nicholasville, KY, USA) for 140 days on skeletal muscle and liver gene transcription in beef steers. Steers fed Amaize had lower average daily gain (p = .

Differential Gene Expression Analysis of Bovine Macrophages after Exposure to the Penicillium Mycotoxins Citrinin and/or Ochratoxin A.

Mycotoxins produced by fungal species commonly contaminate livestock feedstuffs, jeopardizing their health and diminishing production. Citrinin (CIT) and ochratoxin A (OTA) are mycotoxins produced by spp. and commonly co-occur.

Effects of a docosahexaenoic acid-rich microalgae nutritional product on insulin sensitivity after prolonged dexamethasone treatment in healthy mature horses.

Objective: To determine effects of a microalgae nutritional product on insulin sensitivity in horses.

Animals: 8 healthy mature horses. PROCEDURES :Horses (n = 4/group) received a basal diet without (control diet) or with docosahexaenoic acid-rich microalgae meal (150 g/d) for 49 days (day 0 = first day of diet).

Source of selenium supplementation influences testis selenium content and gene expression profiles in Single Comb White Leghorn roosters.

Spermatogenesis is a tightly regulated, selenium-dependent process. Nutritional deficiencies, including Se, have been associated with decreased fertility. During Se depletion, testes preferentially retain Se while other tissues are depleted.

Selenium content in blood fractions and liver of beef heifers is greater with a mix of inorganic/organic or organic versus inorganic supplemental selenium but the time required for maximal assimilation is tissue-specific.

Selenium (Se) content of feedstuffs is dependent on the Se level of the soil. Even though Se in grass and forage crops is primarily present in organic forms, Se is commonly supplemented in cattle diets in an inorganic (sodium selenite) form in geographic regions where Se soil concentrations are low. The purpose of this study was to answer two important questions about inorganic (ISe) vs organic (OSe) forms of dietary supplementation of Se (3 mg/day) to growing beef heifers (0.