Publications by authors named "Kristen Albrecht"
Purpose Of Review: CD4 T cell loss is the hallmark of uncontrolled HIV-1 infection. Strikingly, CD4 T cell depletion is a strong indicator for disease severity in the recently emerged coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We reviewed recent single-cell immune profiling studies in HIV-1 infection and COVID-19 to provide critical insight in virus-induced immunopathogenesis.
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- * The researchers created a method called HIV-1 SortSeq to isolate rare HIV-1-infected cells from individuals where the virus is usually suppressed, analyzing these cells reveals pathways related to RNA decay and viral activity.
- * They discovered that HIV-1 causes unusual transcription in host genes by integrating its RNA and promoting its own activity, which means these processes could be targeted for new treatments to help manage or eliminate HIV-1 persistence.