Publications by authors named "Kristel Milan"
Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct.
Giordano de Guglielmo Lieselot Carrette Marsida Kallupi Molly Brennan Brent Boomhower Kristel K Milan
Elife
November 2024
Article Synopsis
- Addiction involves increased drug use, compulsive seeking, and continued use despite harm, but why some users progress to this point isn't well understood, especially concerning sex differences.
- A study with over 500 diverse rats examining cocaine self-administration revealed that increased drug intake, persistence despite negative consequences, and reward-seeking were interconnected, while irritability during withdrawal stood apart.
- The research found that female rats showed more addiction-like behaviors and fewer resilient traits compared to males, indicating significant sex differences in addiction resilience.
Nicotine use produces psychoactive effects, and chronic use is associated with physiological and psychological symptoms of addiction. However, chronic nicotine use is known to decrease food intake and body weight gain, suggesting that nicotine also affects central metabolic and appetite regulation. We recently showed that acute nicotine self-administration in nicotine-dependent animals produces a short-term increase in food intake, contrary to its long-term decrease of feeding behavior.
View Article and Find Full Text PDF