Retinal and cerebral hemodynamics redistribute to favor thermoregulation in response to passive environmental heating and heated exercise in humans.

Core temperature (T) changes, alongside exercise, affect hemodynamic responses across different conduit and microvascular beds. This study investigated impacts of ecologically valid environmental heat and exercise exposures on cerebral, skin and retinal vascular responses by combining physiological assessments alongside computational fluid dynamics (CFD) modeling. Young, healthy participants ( = 12) were exposed to environmental passive heating (PH), and heated exercise (HE) (ergometer cycling), in climate-controlled conditions (50 mins, 40°C, 50% relative humidity) while maintaining upright posture.

Physiological response to exercise in the heat: Implications for risk mitigation and adaptation.

Purpose: Recent field studies of physical exertion in challenging environmental conditions have reported dissociation between elevation in body core temperature (T) and successful task completion. This prompted us to further examine physiological mechanisms that might underlie variability in the response to exertional heat exposure. We hypothesized that, in response to exercise in the heat, systematic differences in central and peripheral physiological variables would be apparent between participants who successfully completed the task, versus those who became hyperthermic or symptomatic.

Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle.

Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity.

Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse.