Publications by authors named "Krista Tantakoun"
Introduction: Indirect treatment comparisons (ITCs) evaluate novel treatments compared to appropriate comparators when direct evidence is unavailable or infeasible. The objective of this study was to highlight the prevalence of different ITC methods in oncology drug submissions and to provide insights into how ITCs have been used in recent regulatory approval, reimbursement recommendations, or pricing decisions across various regions and diverse assessment frameworks.
Methods: A targeted literature review was conducted to identify assessment documents for oncology drug submissions that included ITCs.
Background: Patients with obstructive hypertrophic cardiomyopathy (oHCM) have a substantial humanistic, clinical, and economic burden due to the array of symptoms and complications associated with the disease. The objective of this review was to identify key evidence gaps related to oHCM, specifically in Europe, North America, and Japan.
Methods: A targeted literature review was conducted using PubMed to identify English-language studies published between 2012 and 2022 assessing patients with HCM/oHCM in France, Germany, Italy, Spain, the United Kingdom (UK), the United States (US), Canada, and Japan.
Background: Although the present diagnosis of acute kidney injury (AKI) involves measurement of acute increases in serum creatinine (SC) and reduced urine output (UO), measurement of UO is underutilized for diagnosis of AKI in clinical practice. The purpose of this investigation was to conduct a systematic literature review of published studies that evaluate both UO and SC in the detection of AKI to better understand incidence, healthcare resource use, and mortality in relation to these diagnostic measures and how these outcomes may vary by population subtype.
Methods: The systematic literature review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.
Article Synopsis
- The study aims to enhance the quality and transparency of indirect treatment comparisons (ITCs) in healthcare by identifying key techniques and assessing their suitability as evidence for healthcare interventions.
- Researchers reviewed 68 guidelines from various global authorities, highlighting a preference for certain ITC methods that account for population differences rather than naive comparisons, with updates reflecting recent clinical needs.
- The findings indicate that while ITCs are valuable for understanding clinical effectiveness when direct trials aren't feasible, the appropriateness of the ITC method depends on data quality and the context of healthcare decisions.