Publications by authors named "Krista M LaPerle"
Article Synopsis
- The study explores how combining IL-12, a cytokine that boosts immune responses, with a specific antibody (mAb 4D5) enhances the anti-tumor effects against HER2-positive colon cancer in mice.
- Results showed that this combination therapy led to significant cancer growth suppression and was linked to increased levels of IFN-γ, a critical immune-signaling molecule.
- Further analysis indicated that the anti-tumor effects were primarily mediated by NK cells, suggesting that using immune-boosting cytokines alongside therapeutic antibodies could improve cancer treatments.
