Advancing toward precision migraine treatment: Predicting responses to preventive medications with machine learning models based on patient and migraine features.

Objective: To develop machine learning models using patient and migraine features that can predict treatment responses to commonly used migraine preventive medications.

Background: Currently, there is no accurate way to predict response to migraine preventive medications, and the standard trial-and-error approach is inefficient.

Methods: In this cohort study, we analyzed data from the Mayo Clinic Headache database prospectively collected from 2001 to December 2023.