Potential influences on initiation and persistence of extramedical prescription pain reliever use in the US population.

Objective: Extramedical prescription pain reliever use has generated much public concern; however, little is known regarding its epidemiology in the general population.

Methods: Using data from the annual National Survey on Drug Use and Health (2002 and 2003), we explored demographics, drug use history, and physical/mental problems associated with recent onset use (initiated in past 24 mo, n=1528) and persistent use (initiated more than 2 y and still using within a year of the assessment, n=4400) of prescription pain relievers when taken without a clinician's prescription or not as prescribed.

Results: Adolescents and young adults were more likely to initiate extramedical use as compared with older individuals.

Individual, interpersonal, and structural correlates of effective HAART use among urban active injection drug users.

Among individuals receiving highly active antiretroviral therapy (HAART), injection drug users (IDUs) are less likely to achieve HIV suppression. The present study examined individual-level, interpersonal, and structural factors associated with achieving undetectable plasma viral load (UVL) among US IDUs receiving recommended HAART. Data were from baseline assessments of the INSPIRE (Interventions for Seropositive Injectors-Research and Evaluation) study, a 4-site, secondary HIV prevention intervention for heterosexually active IDUs.

Medicare interim payment system's impact on Medicare home health utilization.

The Medicare home health interim payment system (IPS) implemented in fiscal year 1998 provided very strong incentives for home health agencies (HHAs) to reduce the number of visits provided to each Medicare user and to avoid those beneficiaries whose Medicare plan of care was likely to exceed the average beneficiary cost limit. We analyzed multiple years of data from the Medicare Current Beneficiary Survey (MCBS) to examine how the IPS affected subgroups of the Medicare population by health and socioeconomic characteristics. We found that the IPS strongly reduced overall utilization, but that few subgroups were disproportionately affected.

Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation.

We examined whether blockade of corticotropin-releasing factor (CRF) receptors by a non-peptide CRF antagonist (DMP696) would attenuate the stress hyper-responsiveness that occurs in response to maternal separation. In a social interaction test as well as the elevated plus maze, adult male rats, which had been maternally separated as infants, displayed more anxiety-like behavior compared with handled rats. DMP696 increased social interaction in both groups.