Sequential Presentation of Obsessive-Compulsive Disorder and Narcolepsy in a 10-Year-Old Girl With Wolfram Syndrome 1.

Wolfram syndrome 1 (WS1) is a rare, autosomal recessive neurodegenerative disorder characterized by diabetes insipidus, insulin-dependent diabetes mellitus, optic atrophy, and deafness resulting from loss-of-function genetic variants in the WFS1 gene. Individuals with WS1 manifest a spectrum of neuropsychiatric disorders. Here, we report a pediatric case of WS1, which stemmed from a novel biallelic WFS1 loss-of-function genetic variant.

Clinical profile of obsessive-compulsive disorder in children.

Introduction: Most studies on obsessive-compulsive disorder (OCD) among children and adolescents pertain to adolescents and Indian data on childhood-onset OCD are scant.

Objective: To evaluate the clinical profile of OCD among children and adolescents with onset before the age of 12 years.

Methods: Children and adolescents who attended the outpatient clinic with a clinical diagnosis of OCD were included in the study.

Early Social Experience and Digital-Media Exposure in Children with Autism Spectrum Disorder.

Objective: To study the early social experience and digital media exposure in children with autism spectrum disorder (ASD) in comparison with typically developed children.

Methods: Details of digital-media exposure and early social experience in 65 children with ASD were compared with those in a control group of equal number of typically developed children, matched for age and gender. Prenatal and perinatal factors were also studied.

Factors Associated With Mortality in Toxic Encephalopathy Due to Shigellosis in Children.

Objective: To study the clinical characteristics and factors associated with mortality among children with Shigella encephalopathy.

Methods: The data collection was done prospectively from January, 2018 to May, 2019 with retrospective data from June, 2016 to December, 2017. The study cohort consisted of 58 children <12 years of age with Shigella encephalopathy admitted to the pediatric intensive care unit.

Cognitive Functions and Psychological Problems in Children with Sickle Cell Anemia.

Objective: To study the cognitive functions and psychological problems in children with Sickle cell anemia (SCA).

Methods: Children with SCA were compared with an age, sex- and community- matched control group of children with no SCA. Malins Intelligence Scale for Indian children, modified PGI memory scale, and Childhood Psychopathology Measurement Schedule were used to assess cognitive functions and psychological problems.

Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.

Unlabelled: Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.