Publications by authors named "Krishnakumar Kesava Pisharady"
Objective: Bilateral subthalamic nucleus deep brain stimulation (STN DBS) improves motor complications and quality of life (QOL) in patients with Parkinson's disease (PD). However, it does not delay or prevent the occurrence of dementia. The deleterious effects of dementia on QOL and activities of daily living (ADL) underscore the importance of identifying predictors of dementia-free survival in PD patients considered for STN DBS.
View Article and Find Full Text PDFArticle Synopsis
- Deep Brain Stimulation (DBS) has been used for nearly 40 years as the primary treatment for Parkinson's disease patients with motor issues, and it also shows potential for other movement disorders.
- While the exact way DBS works is still not fully understood, it likely helps by disrupting abnormal brain activity and improving communication in neuronal circuits.
- The procedure is generally safe when performed by experienced teams, and new techniques and technologies are making DBS more accessible to a larger number of patients.
Surgical Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease.
Ann Indian Acad Neurol
January 2017
The treatment of motor manifestations of Parkinson's disease (PD) is essentially a trade-off between adequate relief of motor symptoms and prevention and control of motor complications, particularly levodopa-induced dyskinesia (LID). Progression of PD is paralleled by a progressive difficulty in achieving the balance. Functional neurosurgical procedures provide sustained relief of LID in carefully selected patients when further tailoring of medical therapy fails to achieve this goal.
View Article and Find Full Text PDFAim: The duration of improvement in quality of life after subthalamic nucleus deep brain stimulation (STN DBS) for Parkinson's disease (PD) and the presurgical identification of factors predicting sustained clinical benefits have implications in patient selection and timing of surgery. These aspects were assessed in patients who underwent yearly assessment for at least 7 years after surgery.
Materials And Methods: The quality of life, motor and cognitive outcomes of 25 patients who completed the 7-year assessment, and 12 patients who completed the 10-year assessment, were analyzed.