Publications by authors named "Krishna Swaroop Desireddy"
Article Synopsis
- There is a pressing need for new antiviral drugs, and research shows that the drug 6-thioguanine (6-TG) can inhibit the replication of viruses like HCoV-OC43 and SARS-CoV-2.
- 6-TG disrupts early infection processes by causing issues with the Spike protein, preventing the viruses from effectively replicating and assembling.
- The antiviral activity of 6-TG requires it to be converted into a specific nucleotide form, and further studies indicate that it might target an unidentified small GTPase, presenting a potential avenue for developing host-targeted antiviral therapies.
A series of novel pyrido[1,2-a]pyrimidine-3-carboxamide derivatives 6a-n were prepared starting from 2(1H) pyridone 1 via hydrolysis, de-carboxylation, selective O-alkylation followed by rearrangement to give pyridine-2-amine 3. Compound 3 on reaction with ethoxy methylene malonic diethyl ester (EMME) under a conventional method followed by cyclization under micro wave irradiation (MWI) conditions resulted in product 5. Compound 5 on coupling with diverse substituted aliphatic amines formed title compounds 6a-n.
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