Publications by authors named "Krishna Pedaprolu"
Article Synopsis
- Overuse is a major risk factor for tendinopathy, but the specific fatigue-induced damage leading to tendon degeneration is not well understood.
- This study investigates whether cyclic loading leads to collagen denaturation and fiber disorganization in mouse Achilles tendons, finding that while disorganization occurs, collagen denaturation is minimal.
- The study also compares the Achilles tendon to other mouse tendons and suggests that its resistance to collagen denaturation may indicate that its degeneration is not primarily caused by mechanical damage to collagen structures.
There is considerable scientific interest in understanding the strains that tendon cells experience in situ and how these strains influence tissue remodeling. Based on this interest, several analytical techniques have been developed to measure local tissue strains within tendon explants during loading. However, in several cases, the accuracy and sensitivity of these techniques have not been reported, and none of the algorithms are publicly available.
View Article and Find Full Text PDFA major risk factor for tendinopathy is tendon overuse (i.e., fatigue loading).
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