Correlation analysis between the in vivo bioavailability and in vitro bioaccessibility of nitro PAHs in soil: Application of simplified FOREhST in vitro methods based on the Chinese pharmacopoeia.

In this study, the relative bioavailability (RBA) of nitrated polycyclic aromatic hydrocarbons (NPAHs) in soil samples (n = 30) was assessed using an in vivo mouse model. Based on the correlation between the bioaccessibility data obtained from the Tenax improved traditional Fed ORganic Estimation human Simulation Test (FOREhST) in vitro method (TITF) and the bioavailability data obtained from in vivo experiments, the TITF method was further optimized and simplified by referring to the "Pharmacopoeia of the People's Republic of China: Volume IV, 2020" to adjust the formulation and parameters of the gastrointestinal fluid (GIF) in order to establish a simpler and lower cost in vitro method for the determination of the bioaccessibilities of NPAHs. The dose-accumulation relationship of the in vivo experiment showed that the linear dose-response was better in adipose tissue (R = 0.

Bioaccessibility and bioavailability of NPAHs in soils using in vitro-in vivo assays: Comparison of laboratory and outdoor environmental aging effect.

Aging process is one of the most important factors that markedly reduces bioaccessibility and bioavailability (bioac-bioav) of organic contaminants. However, only few data on comparison of the effects of laboratory artificial aging (LAA) and outdoor environmental aging (OEA) processes on nitrated polycyclic aromatic hydrocarbons (NPAHs) bioac-bioav are available. In the current study, oral bioac-bioav of NPAHs in LAA and OEA soils (aging time intervals: 0, 45, 90, 120 and 150 d) were measured by in vitro traditional Fed ORganic Estimation human Simulation Test (FOREhST) and Tenax improved FOREhST (TI-FOREhST) methods, and in vivo mouse model.

Screening of antimicrobials, fragrances, UV stabilizers, plasticizers and preservatives in sewage treatment plants (STPs) and their risk assessment in India.

Community/industrial wastewater is the prime source of anthropogenic chemicals, its treatment is often a daunting task and unaffordable for many countries. Emerging Contaminants (ECs) have been drained into wastewater after continuous use/misuse and Conventional treatments in STPs do not remove them completely. ECs including antimicrobial agents, synthetic musks, Benzotriazole UV stabilizers (BUVSs), plasticizers, and preservatives are frequently reported in environment, and cause health effects to non-target organisms.

Evaluating the adsorption performance of Tenax TA® in different containers: An isolation tool to study the bioaccessibility of nitro-PAHs in spiked soil.

The improved in vitro gastrointestinal simulation methods, with the addition of the adsorption sink, are considered as a promising tool for predicting the bioaccessibility of contaminants. However, the problem associated with the recovery of the adsorption sink from the complex matrix needs more understand. Although previous studies tried to solve this shortcoming by using the containers (a vessel to hold the adsorption sink), there is no systematic comparison study on the impact of containers on bioaccessibility till now, especially for nitro-polycyclic aromatic hydrocarbons (nitro-PAHs).

Investigation of distribution, sources and flux of perfluorinated compounds in major southern Indian rivers and their risk assessment.

Perfluorinated compounds (PFCs) are a group of emerging contaminants still less reported in rivers, particularly southern India. Therefore, we investigated the fate of 13 PFCs in three major rivers in southern India during post-monsoon and summer seasons. Twelve PFCs were detected, with an average total PFCs of 1853 ± 1463 pg/l.

Occurrence of triclocarban and benzotriazole ultraviolet stabilizers in water, sediment, and fish from Indian rivers.

Triclocarban and benzotriazole ultraviolet stabilizers (BUVSs) are listed as high production volume synthetic chemicals, used extensively in personal care products. Many of these chemicals persist in the aquatic environment as micropollutants. Knowledge on their fate in freshwater ecosystems is still lacking, especially in the Indian Rivers.

Evaluating spatial distribution and seasonal variation of phthalates using passive air sampling in southern India.

Usage of phthalates as plasticizers has resulted in worldwide occurrence and is becoming a serious concern to human health and environment. However, studies on phthalates in Indian atmosphere are lacking. Therefore, we studied the spatio-temporal trends of six major phthalates in Tamil Nadu, southern India, using passive air samplers.

Phthalate esters in water and sediments of the Kaveri River, India: environmental levels and ecotoxicological evaluations.

Phthalate esters are well known for their environmental contamination and toxicological effects as "endocrine disruptors." In this study, environmental levels of phthalate esters and ecotoxicological risk assessments were performed in one of the major rivers in India, the Kaveri. Water and sediment samples were collected during 2010-2012 representing the major stretch of the river and extracted by solid-phase and ultrasonic methods, respectively, and analyzed for six major phthalates by using a gas chromatograph-mass spectrometer.

Paraben resistance in bacteria from sewage treatment plant effluents in India.

Parabens, the antimicrobial preservatives used in cosmetics, food and pharmaceuticals, are often detected in the aquatic environment. Generally, sewage treatment plants (STPs) receive community sewage containing parabens, which are ultimately released into streams/rivers. In this study, bacteria in STP effluents were evaluated for their resistance to parabens.

GC-MS determination of bisphenol A and alkylphenol ethoxylates in river water from India and their ecotoxicological risk assessment.

Water samples from three rivers in southern India were analyzed for octylphenol (OP), nonylphenol (NP), and bisphenol A (BPA) residues by gas chromatography and mass spectrometry. The concentrations of OP, NP and BPA ranged from ND (not detected) to 16.3 ng/L, ND to 2200 ng/L, and 2.

Non-steroidal anti-inflammatory drugs in Indian rivers.

Pharmaceutical concentration data for Indian surface waters are currently scarce. Sewage often enters Indian rivers without prior treatment, and so previously reported environmental concentrations from regions with routinely implemented sewage treatment cannot simply be used to predict concentrations in Indian surface water. Improved knowledge of pharmaceutical concentrations in Indian waters would enable determination of potential risks posed to aquatic wildlife and human health in this region.