Secondary metabolite profiling using HR-LCMS, antioxidant and anticancer activity of PSMS6 methanolic extract: and study.

Novel anticancer drugs of natural origin have increased tremendously due to the resistance of multiple chemotherapeutic drugs in breast cancer therapy and their high toxicity with undesirable side effects. The study investigates the bioactivity of secondary metabolites derived from PSMS6 isolated from marine soil sediment in the Velar estuary, Parangepattai, Cuddalore district, Tamil Nadu, and India. Strains were isolated and antagonistic activity was screened using the agar well diffusion method.

Rejuvenation of bone volume with CGF and i-PRF in intra-osseous defects.

The risk of further periodontal breakdown increases with a deep intrabony defect. Non-surgical periodontal therapy could pose a challenge and surgical intervention is mainly required to manage the defect. Autologous platelet concentrates such as Injectable platelet rich fibrin (i-PRF) and concentrated growth factor (CGF) may improve surgical outcome due to its enrichment with growth factors.

Temporal profile of serum melatonin levels in paediatric pineal tumours subjected to surgery: newer insights.

Introduction: Pineal tumours (PTs) are rare and histologically variable. Serum melatonin is a well-known product of this gland, albeit with uncertain clinical implications vis-à-vis its utility as a potential tumour marker. In particular, the temporal profile of serum melatonin during the disease course remains unclear and infrequently studied.

Biomolecular characterisation of marine microalga in comparison to fishmeal and soymeal as an alternative feed ingredient.

Introduction: Marine microalgae protein has better solubility and digestibility than other protein-based feeds. Apart from protein, high-value biomolecules have an immense potential to enhance the quality of feed, but knowledge about them is scarce.

Objective: Marine microalga Picochlorum sp.

Dynamic magnetic resonance imaging parameters for objective assessment of the magnitude of tethered cord syndrome in patients with spinal dysraphism.

Background: Dynamic magnetic resonance imaging (MRI)-based criteria for diagnosing magnitude of tethered cord syndrome (TCS) in occult spinal dysraphism are proposed.

Methods: In this prospective, case-control design study, MRI lumbosacral spine was performed in 51 subjects [pilot group (n = 10) without TCS (for defining radiological parameters), control group (n = 10) without TCS (for baseline assessment), and study group (n = 31) with spinal dysraphism (thick filum terminale [n = 12], lumbar/lumbosacral meningomyelocoele [n = 6], and lipomyelomeningocoele [n = 13])]. The parameters compared in control and study groups included oscillatory frequency (OF), difference in ratio, in supine/prone position, of distance between posterior margin of vertebral body and anterior margin of spinal cord (oscillatory distance [OD]), with canal diameter, at the level of conus as well as superior border of contiguous two vertebrae above that level; delta bending angle (ΔBA), difference, in supine/prone position, of angle between longitudinal axis of conus and that of lower spinal cord; and sagittal and axial root angles, subtended between exiting ventral nerve roots and longitudinal axis of cord.

Gastric duplication cyst in an infant presenting with non-bilious vomiting.

In an infant presenting with a mass in the abdomen and non-bilious vomiting, duplication cyst needs to be considered in the list of differential diagnoses. Gastric duplication cyst is an uncommon occurrence in children. Diagnosis is based on clinical findings and imaging features.

Hepatic venous outflow obstruction in paediatric liver transplantation.

Introduction: Vascular complications after orthotopic split liver transplantation in children result in significant post-operative complications.

Materials And Methods: A review of children undergoing liver transplantation from 2004 to 2006 was undertaken. The data was obtained based on a proforma-based analysis.

Retroperitoneal approach for laparoscopic nephrectomy is feasible in a child with difficult access due to severe scoliosis.

Retroperitoneal minimal access surgery has been widely described and practiced in many paediatric urology units. However, retroperitoneal laparoscopic nephrectomy performed in the presence of severe scoliosis has not been described in the literature before. We report a challenging case of a 13-year-old girl with severe scoliosis requiring a nephrectomy.

Ataxia-telangiectasia and hepatocellular carcinoma.

Ataxia-telangiectasia (AT) is a multi-system disease involving the cerebellum, cutaneous blood vessels and the immune system including both cellular and humoral components. It also involves hematological, endocrine and peripheral nervous systems. This disease is often associated with abnormal liver function tests, such as, raised alkaline phosphatase and various nonspecific histological changes in the liver.