Publications by authors named "Krishna D Bharwani"
Article Synopsis
- * Conducted over four years, the research included 53 CRPS patients, mainly with long-term symptoms, and analyzed their serum sIL-2R levels alongside a CRPS severity score.
- * Results showed no significant correlation between serum sIL-2R levels and CRPS severity, indicating it may not be a useful biomarker for long-standing cases, and suggesting further studies on sIL-2R levels from early to persistent CRPS.
Article Synopsis
- Complex regional pain syndrome (CRPS) is a tough condition that causes long-lasting pain in arms or legs, and some people might feel better after getting esketamine treatment.
- This study compares two ways to give esketamine: one method is a long, continuous treatment in a hospital, and the other is shorter treatments done every two weeks at home.
- The goal is to see if the home treatment works just as well as the hospital one, while also checking how safe and cost-effective these treatments are for patients.
Complex regional pain syndrome (CRPS) is a debilitating painful condition of a distal extremity that can develop after tissue damage. CRPS is thought to be a multimechanism syndrome and ideally the most prominent mechanism(s) should be targeted by drugs in an individually tailored manner. This review gives an overview of the action and evidence of current and future pharmacotherapeutic options for CRPS.
View Article and Find Full Text PDFObjectives: Ketamine is used to treat chronic refractory pain. However, there are no scientific guidelines for ketamine use in the Netherlands. The aim of this survey was to provide an overview of the use of ketamine for chronic pain in the Netherlands.
View Article and Find Full Text PDFObjective: The objective of this study was to assess the effectiveness of a low-dose intravenous S-ketamine treatment on refractory pain in patients with Complex Regional Pain Syndrome (CRPS).
Methods: In this retrospective study, patients with CRPS who received intravenous S-ketamine from March 2010 to April 2019 were included. According to our inpatient protocol, S-ketamine dose was increased until pain reduction was achieved or side effects were observed.
Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left untreated, it can have a significant impact on the quality of life of patients. The diagnosis of CRPS is currently based on a set of relatively subjective clinical criteria: the New International Association for the Study of Pain clinical diagnostic criteria for CRPS.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the role of T-cells and their activity in complex regional pain syndrome (CRPS), a condition thought to involve the immune system.
- It found that CRPS patients had significantly higher levels of soluble interleukin-2 receptor (sIL-2R) in their blood compared to healthy individuals, suggesting increased T-cell activity.
- The elevated sIL-2R levels could serve as a reliable marker for CRPS and may lead to the development of new anti-inflammatory treatments for the disease.