Capsaicin-Induced Endocytosis of Endogenous Presynaptic Ca2.2 in DRG-Spinal Cord Co-Cultures Inhibits Presynaptic Function.

The N-type calcium channel, Ca2.2 is key to neurotransmission from the primary afferent terminals of dorsal root ganglion (DRG) neurons to their postsynaptic targets in the spinal cord. In this study, we have utilized Ca2.

Involvement of Ca 2.2 channels and α δ-1 in homeostatic synaptic plasticity in cultured hippocampal neurons.

In the mammalian brain, presynaptic Ca 2 channels play a pivotal role in synaptic transmission by mediating fast neurotransmitter exocytosis via influx of Ca into the active zone of presynaptic terminals. However, the distribution and modulation of Ca 2.2 channels at plastic hippocampal synapses remains to be elucidated.