Publications by authors named "Kris M Barreto"
Article Synopsis
- IGF-1R is frequently overexpressed in epithelial cancers, contributing to tumor growth and therapy resistance, but anti-IGF-1R monoclonal antibodies have shown limited success in improving patient outcomes.
- In a study using the triple-negative breast cancer model (SUM149PT), the humanized monoclonal antibody cixutumumab was successfully conjugated and radiolabeled for use in both imaging and radiotherapy, maintaining high affinity for IGF-1R.
- Cixutumumab treatment led to prolonged survival in tumor-bearing mice, with low specific activity radiolabeling showing particularly promising results, including complete tumor remission in some cases.
