Sex hormones and repolarization dynamics during the menstrual cycle in women with congenital long QT syndrome.

Background: Women with congenital long QT syndrome (LQTS) experience increased cardiac event risk after the onset of adolescence, perhaps stemming from the known modulating effects of sex hormones on the cardiac potassium channels.

Objective: We hypothesized that the effect of sex hormones on cardiac ion channel function may modify electrocardiographic (ECG) parameters associated with the propensity for ventricular tachyarrhythmias during the menstrual cycle in women with LQTS.

Methods: We prospectively enrolled 65 women with congenital LQTS (type 1 LQTS [LQT1], n = 24 [36.

Use of oral contraceptives in women with congenital long QT syndrome.

Background: Use of oral contraceptives (OCs) may modulate the clinical course of women with congenital long QT syndrome (LQTS). The safety of OC use by sex hormone content has not been assessed in women with LQTS.

Objective: We aimed to evaluate the association of OCs with the risk of cardiac events (CEs) in women with LQTS.

Clinical aspects of the three major genetic forms of long QT syndrome (LQT1, LQT2, LQT3).

Background: A comprehensive report on the clinical course of the three major genotypes of the long QT syndrome (LQTS) in a large U.S. patient cohort is lacking.