Ruthenium-catalyzed electrochemical C-H activation of benzamidine hydrochlorides with internal alkynes for the synthesis of 1-aminoisoquinolines.

A constant current electrochemical approach for the synthesis of 1-aminoisoquinoline derivatives through the Ru(II)-catalyzed annulation of benzamidine hydrochlorides with alkynes is reported herein. This method produces good yields of naphthyridine-based compounds Ru(II)-catalyzed C-H bond cleavage, leading to the formation of new C-C and C-N bonds in a one-pot manner. Notably, the synergy of electricity and Ru catalysis offers broad reaction compatibility, accommodating a wide range of substrates with diverse steric and electronic properties.

An Electrochemical Method for Carboxylic Ester Synthesis from N-Alkoxyamides.

An electrochemical method for the synthesis of carboxylic as well as hindered esters from N-alkoxyamides has been reported. The electrochemical reaction proceeds through constant current electrolysis (CCE) by taking advantage of the dual role of n-BuNI (TBAI) as the redox catalyst as well as the supporting electrolyte. Besides providing mild reaction conditions, the present protocol is free from external oxidants and conducting salts, thereby generating nitrogen as the nonhazardous side product.