[Problem of pathogenesis of Mycoplasma infection].

It has been shown that irrespective of the primary focus of affliction, M. hominis-induced infection should be regarded as a systemic disease characterized by an immune-mediated inflammation which is contributed to by blood kallikrein-kinin system activation resulting in changes in the coagulative system and fibrinolysis until disseminated intravascular coagulation develops. This allows one to interpret in a new fashion the etiology of some diseases proceeding with signs of vasculitis.

[The kallikrein-kinin system of allogeneic renal transplant].

The parameters of kallikrein-kinin system (KKS) in the renal graft tissue (the cortex and medulla) and urine in 10 rats were investigated 4, 8 and 12 days after transplantation prior to the clinical symptoms of graft rejection. Controllable activation of a kinin-generative link of KKS (more pronounced in the medulla than in the cortex) is found. It manifests itself in growth of the kallikrein activity (in proportion to terms of transplantation) and in an increase of the inhibitor level.

[Changes in the kallikrein-kinin system as a result of electrical-medicinal anesthesia].

The results of kallikrein-kinin system studies are analysed in 105 urological patients at different stages of surgical treatment. It has been established that changes in kallikrein-kinin system during combined electrical and drug anesthesia as well as during ataralgesia are unidirectional and reside in moderate system activation of compensatory nature. It is concluded that combined electrical and drug anesthesia is an adequate anesthetic technique to be used during urological surgery.

[Mechanisms of hypertension in patients with terminal kidney failure on programmed hemodialysis].

The state of some mechanisms involved in AP regulation was studied in 18 patients with terminal renal failure (TRF) on programmed hemodialysis for 7-9 mos. The imbalance of extra- and intracellular sodium, potassium and water causing hypertension, was noted in TRF patients. TRF patients revealed (against a background of the normal activity of plasma renin) a high activity of carboxycathepsin resulting in the creation of conditions for enhanced kinin degradation playing a depressor role and for intense angiotensin II formation, being an important mechanism of persistent hypertension.

[State of the blood prekallikrein-kallikrein system in patients with glomerulonephritis as affected by pathogenetic therapy].

A study was made of the effect of the treatment with glucocorticoids (GC), cyclophosphamide and indocide on the prekallikrein-kallikrein system (PKKS) of the blood in 108 patients with glomerulonephritis. It was revealed that in patients with acute and chronic GN, the PKKS was activated before treatment. The PKKS activation was marked by a decrease in the content of prekallikrein and elevation of the alpha 2-macroglobulin content, particularly in patients with the nephrotic syndrome.

[Energy metabolism in subcellular fractions of normal and acute ischemic kidneys].

The level of oxidative phosphorylation, activity of phosphofructokinase, fructose-1,6-diphosphate aldolase, ketose-1-phosphate aldolase, glucose-6-phosphatase and lactate dehydrogenase are determined in subcellular fractions in the kidney cortex layer of rabbits which have suffered from acute ischemia (for 15, 30, 60, 120 min). Ischemia inhibits the oxidative processes in mitochondria which is proportional to the duration of the effect. An increase in the activity of glycolytic chain enzymes in microsomes and soluble fraction for 15-30 min of ischemia evidences for a compensation of the energy losses at the expense of glycolysis with short periods of ischemia.

[Effect of the protease inhibitor contrical on oxidative phosphorylation and proteolysis in kidney under thermal ischemia].

Morphological (at the tissue, cellular and subcellular levels) and biochemical (determination of the autolysis intensity, proteolytic activity for casein and BAPNA splitting, the level of oxidation phosphorylation) methods were used to show that a preliminary administration to the animal organism of contrical, an inhibitor of proteases partially prevents the kidneys, which endured a two-hour ischemia from development of irreversible changes, favours the preservation of the renal parenchyma structure, and stabilizes the energy status of cells.