[Chemical compatibility of ketamine and midazolam in infusion solutions].

The chemical compatibilities of intravenous (i.v.) solutions containing ketamine and midazolam were investigated by UV/VIS spectroscopy, IR spectroscopy, and high-performance liquid chromatography (HPLC).

[The physical compatibility of ketamine and diazepam in infusion solutions].

Physical compatibilities of infusion solutions containing ketamine and diazepam or midazolam in different concentrations were studied by visual examination and by light-scattering measurements. The isotonic infusion solutions used were fructose 5%, glucose 5%, and NaCl 0.9%.

[The relief of postspinal headache using the Whitacre cannula. A clinical study].

In a prospective study spinal anesthesia was performed in 500 patients (338 male and 162 female patients between 16 and 91 years of age: mean 46 years), with a total number of 603 spinal anesthetics. In all cases a 22G Whitacre needle was used. All patients were mobilized from the day of the operation onward and visited 4 days later by the interviewer and asked about any symptoms, especially headache.

[The relief of postspinal headache using the Whitacre cannula. Experimental studies].

The structure of the spinal dura mater and the consequences of puncturing the dural tissue with different types of spinal needles were examined. There is no uniformly longitudinal parallel arrangement of dural fibers in human lumbar dura mater from the segments L3-5, but as shown in both scanning electron microscope imaging and polarized light microscopy the small collagenous fibrils are connected by cross-linked bridges. After perforation with Whitacre's pencil-point needle a kind of double layer membrane surrounds the puncture hole and might be responsible for the rearrangement of dural fibers and sealing of the hole after removal of the needle, like wings closing over each other (curtain-effect).

Investigations of the sensory blockade effect of perineurally injected ethanol on the tail nerve of the mouse.

The effect of an alcohol block on the conduction of sensory stimuli in the tail nerve of the mouse was investigated using the perineural injection of solutions of ethanol (35, 40 and 45%). One hundred and fifty white mice of either sex were given 2 X 0.03 ml of the relevant alcohol solution into both sides of the tail.

[Renal and circulatory function under ketamine anesthesia. An experimental study on animals (author's transl)].

Cardiac output, glomerular filtration rate, stroke volume, heart rate, and urinary output were determined in 10 mongrel dogs. Under the conditions of the experiment it was observed that in contrast to man cardiac and renal output as well as stroke volume declined significantly. Heart rate showed no significant change.