Consecutive Transformations of Tetrafluoropropenes: Hydrogermylation and Catalytic C-F Activation Steps at a Lewis Acidic Aluminum Fluoride.

Functionalization reactions of the refrigerants HFO-1234yf (2,3,3,3-tetrafluoropropene) and HFO-1234ze (1,3,3,3-tetrafluoropropene) were developed. The selectivity and reactivity towards CF groups of C-F activation reactions can be controlled by employing either a germane or a silane as the hydrogen source. Unique transformations were designed to accomplish consecutive hydrogermylation and C-F activation steps.

Four-year follow-up of acromegalic patients treated with the new long-acting formulation of Lanreotide (Lanreotide Autogel).

Lanreotide Autogel (Ipsen) is a long-acting somatostatin analogue (SA) in a new galenic formulation suitable for subcutaneous (s.c.) injection.

Early ultrastructural changes of myocardial endothelial cells in traumatic haemorrhagic shock in rats.

The aim of this study was to assess early traumatic haemorrhagic shock (THS)-induced changes in myocardial endothelial cells (mECs) both morphologically and morphometrically. The mECs of capillaries of the left ventricular myocardium were investigated by electron microscopy 15, 30, 60, and 120 min after a standardised THS and compared to a control group. With the use of a computer-assisted image analysis system, we measured the following morphometric parameters--height, area, circumference, cytoplasmic processes, and interendothelial junctions--and determined the number and distribution of cytoplasmic vesicles in every mEC.

Swelling of capillary endothelial cells contributes to traumatic hemorrhagic shock-induced microvascular injury: a morphologic and morphometric analysis.

The endothelial cell (EC) response during the first 2 h after traumatic hemorrhagic shock (THS) was analyzed in the rat mesentery by electron microscopy. Using a computer-assisted image analysis system, we interactively measured THS-induced changes of the area and the mean height of EC as well as the number of swollen EC occluding the capillary lumen. Analysis distinguished between capillaries presenting with the lumen blocked by corpuscular blood cells and capillaries with an open lumen.

Cytoskeletal alterations in endothelial cells of mesenteric microcirculatory bed in experimental traumatic haemorrhagic shock.

The purpose of our investigations was to answer the question of whether an increased number of cytoskeletal structures (CSS) in endothelial cells (EC) of the mesenteric terminal vascular bed will be seen in the early phase of a traumatic haemorrhagic shock (THS). A THS was induced in 32 adult R-rats according to a standardized model (fracture of right heel and withdrawal of one third blood volume through carotid catheter). Eight animals each time were killed 15, 30, 60, and 120 minutes after shock induction.

[Ultrastructural changes in the endothelial cells of the mesenterial terminal blood stream track during the first two hours of a traumatic hemorrhagic shock (THS)].

Ultrastructural changes of endothelial cells of the mesenteric microcirculatory bed were morphometrically and statistically examined on a total of 32 male R-rats 15, 30, 60, and 120 min after a traumatic-haemorrhagic shock (THS). Significant changes of various parameters were observed at all times after shock compared with a control group (8 animals). The findings can be divided into 2 main forms of reaction, namely activation and injury.

[Increase in the cytoskeleton of endothelial cells in mesenteric microvessels in experimental traumatic hemorrhagic shock].

Traumatic haemorrhagic shock in male rats caused an increase of cytoskeletal, especially filaments, in the numerous endothelial cells of the mesenteric microvessels during an examination period of 15 minutes to 2 hours. The filaments become ultrastructurally visible especially in endothelial cells with an enhanced "activity", in case of attachment of cells and in narrow capillaries with stasis. Additional investigations of these findings with other results will be carried out.

[Hemangiopericytoma of the uterus].

Uterine hemangiopericytoma is reported in a 49 years old woman. It is a very rare tumour. The treatment of choice is total hysterectomy with bilateral salpingo-oophorectomy.

Alterations in the intestinal microvillous surface area during the whole life span of the female rat ileum.

The present EM morphometric analysis is a continuation of a series of studies in which the changes of the microvillous surface area of the small intestine was investigated in the course of the entire life span of the female rat. It was concluded from the present data that the alterations of the ileal microvillous surface area are more balanced in the young, pregnant, lactating, adult, old and senile animals than that was observed in the case of the duodenum and jejunum. Positive correlations were found between the parameters height and surface area and, density and surface area measures of the microvilli.

[Morphometric and densitometric studies on the ultrastructure of endothelial cells in capillaries in tumor bearing rats].

The permeability of tumor capillaries to higher molecular substances like albumin and beta-globulin is increased. The comparison of permeability is associated with a modification of the ultrastructure of the capillary wall, especially of endothelial cells and their nuclei. On micrographs of blood capillaries Zajdela-Ascites-Hepatoma pregnanted rats we've studied a) morphometrically the surface and the volume of endothelial cell nuclei in relation to the time after tumor implantation, b) densitometrically the Hetero-Euchromatin-ratio in the nuclei of the same cells in relation to tumor time too.

[On the angio-architecture of intramuscularly implanted Yoshida-sarcoma in untreated and lithium carmine-treated rats (author's transl)].

Investigations were made on the angio-architecture of intramuscularily implanted Yoshida-sarcomas in untreated Wistar-rats and in animals treated with lithium carmine. The injected quantity of lithium carmine led to RES-activation according to the data in the literature. The presentation of the vessels was made by corrosion technique using the synthetic material KALLOCRYL after rinsing the vessels with the proper ester.