Publications by authors named "Krekeler G"

Up to 30% of women experience early miscarriage due to impaired decidualization. For implantation to occur, the uterine endometrial stromal fibroblast-like cells must differentiate into decidual cells, but the genes required for decidualization have not been fully defined. Here, we show that Malignant Brain Tumor Domain-containing Protein 1 (MBTD1), a member of the polycomb group protein family, is critical for human endometrial stromal cell (HESC) decidualization.

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Overexpression of p16 has been demonstrated to be strongly related to the presence of HPV16, 18. Squamous cell carcinoma of the head and neck has been shown to be associated with human papillomavirus (HPV) infection. The main aim of this study was to investigate the relationship between HPV presence and p16 expression in a representative collection of 60 head and neck carcinomas by tissue microarrays.

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Insufficient bone height in the posterior area of the maxilla, due to expansion of the maxillary sinus and atrophic reduction of the alveolar process of the maxilla, represents a contra-indication for insertion of dental implants. This anatomic problem can, in many cases, be solved by augmentation of the floor of the maxillary sinus. This surgical technique was introduced by Tatum.

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Between 1994 and 1999, 50 patients were treated with either profound parodontopathy (30) or periimplantitis (20). Half of each of the two groups of patients was treated conventionally, and the other half was treated with laser support. Before the operation, microbiological examinations were carried out, in addition to registering the clinical findings and taking x-rays.

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In the continuous search for the ideal grafting material in this study the authors used human demineralized freeze dried bone (DFDB) in the maxillary sinusfloor elevation surgery. In total 30 sinusgrafts were performed in 24 patients. Residual lateral maxillary bone height was less than 8 mm but more than 4 mm.

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Limited bone height restricts the use of long dental implants, so short implants may be selected in these situations. Recent reports on clinical results with short implants have been negative, however, and have suggested that indications for the use of these implants are limited. To verify these findings, a multicenter study of short ITI implants was carried out.

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The length of the dental root and the diameter of the tooth neck are odontometric parameters which to date have rarely been used for the differentiation of the sexes. Teeth of 166 individuals from the early medieval burial ground of Eichstetten (south Germany) were available for examination. A correlation analysis was performed to show the possible dimensional interrelation of teeth which, however, applies only to the dental neck parameters.

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Osteo-integratable dental implant systems were developed 25 years ago. The mean life of such implants is about 20 years when they are properly inserted for the right indications. The most important indication is the edentulous mandible, but also the toothless maxilla, the free-end situation in the case of bridges, and single-tooth replacement.

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Bacteroides forsythus has been associated with destructive adult periodontitis. Up to now, detailed analysis by classical means was hampered by the fastidious nature of the organism. There is hope that the application of molecular detection methods such as indirect immunofluorescence or in situ hybridization (ISH) will allow for more rapid and accurate identification.

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The edentulous mandible provides a frequent indication for oral implants. In many cases implants are placed in the interforaminal region to support fixed prostheses or give retention to removable overdentures. One of the hazards of this seemingly safe surgical area is hemorrhage of the floor of the mouth.

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The issues of bone necrosis and implant bed congruency are both central to the success or failure of endosseous dental implants to achieve osseointegration. Use of internally irrigated drilling instruments has been postulated to minimize bone necrosis. The ability of the cutting instruments to produce a smooth, congruent implant bed and retain fine bone structures is also critical to achieving primary integration.

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Small bone defects due to atrophic, traumatic or periodontal bone loss can be grafted with autologous bone grafts taken from the maxillary tuberosity. This study presents a 1-3 years follow-up of 22 patients who were treated according to this technique. Thirty-two implants were placed 6 months after bone grafting.

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Although most retention problems of prostheses are concentrated in the mandible, patients have similar problems in the maxillae. Retention of prostheses can be improved by the use of two or four implants, either with retentive anchors or with a bar in the frontal part of the maxillae. The method of planning and placement of I.

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The International Team for Oral Implantology (ITI) Bonefit system has been introduced as an extended and improved system with respect to titanium plasma-sprayed screws and the F-type implant. The clinical results of the Bonefit implant system were at least as good as those of the F-type implant. The Bonefit system, however, offers more indications and applications, especially in crowns and bridgework.

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Oral implants placed in the atrophic mandible often lack sufficient surrounding attached keratinized gingiva. Although mobile mucosa surrounding the implant does not necessarily need to be replaced, many oral surgeons and dentists prefer attached, keratinized gingiva, especially in cases where oral hygiene is imperfect. This article discusses a method of palatal mucosa transplantation to improve the implant recipient site.

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Analysis of the subgingival microflora has recently implicated Actinobacillus (Haemophilus) actinomycetemcomitans and several black Bacteroides species in the aetiology of juvenile, adult and rapidly progressing periodontitis. Rapid bacteriological diagnosis has been hampered by the slow growth and fastidious nature of these bacteria. To construct diagnostic probes, dideoxy sequencing of the 16S rRNA molecules from A.

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