Positive endocervical curettage in patients with satisfactory and unsatisfactory colposcopy: clinical implications.

We studied a total of 177 patients with cervical intraepithelial neoplasia or invasive carcinoma to evaluate the clinical implications of a positive endocervical curettage. All patients underwent cervical conization. One hundred and ten women had unsatisfactory colposcopy; 67 had satisfactory colposcopy.

Influence of chlorhexidine on seminal patterns in stallions.

Ejaculates were collected at 3-day intervals before, during and after a washing procedure with chlorhexidine (2%). Semen motility and pathology were determined before and after deep-freezing. Blood samples were taken before and within 1 h after washing procedures and then extracted in ether.

Prophylactic topical 5-fluorouracil following treatment of human papillomavirus-associated lesions of the vulva and vagina.

Ninety patients were studied in a controlled, randomized fashion to evaluate the effectiveness of topical 5-fluorouracil in reducing the recurrence rate of human papillomavirus-associated lesions of the vulva and vagina. Following complete ablation of the lesions by one or more treatment modalities, 45 patients applied a single dose of 5% 5-fluorouracil cream biweekly to the vagina and/or vulva for at least six months. Forty-five patients used no prophylactic 5-fluorouracil cream.

Intestinal injury in gynecologic surgery: a ten-year experience.

From 1973 to 1982, a total of 128 incidents of intestinal injury were recorded in patients undergoing gynecologic operations. Of all lacerations, 37% occurred during entrance into the peritoneal cavity, 35% during lysis of adhesions or performance of pelvic or abdominal dissections, 10% during laparoscopy, 9% during vaginal operations, and 9% during dilatation and curettage and dilatation and evacuation. Injury involved the small intestines in 75% and the large intestines in 25% of the cases.

Folding kinetics of mammalian ribonucleases.

The folding kinetics of seven different pancreatic ribonucleases are compared both under native conditions and within the unfolding transition. In general, the folding kinetics of these proteins are similar despite numerous amino acid substitutions. Ribonucleases with 4-6 proline residues show 80% slow-folding species.

[Venomous animals and their venoms].

Animal venoms have aroused great interest during the past decades. During recent years, especially substances from marine animals have been investigated, not only in regard to their chemical structures but also to their biological relevance. Neurotoxic peptides from scorpions opened new aspects of action mechanisms on cell membranes; from snake venoms also ingredients have been obtained which serve as valuable pharmaceutical drugs.

Role of Ca 125 as tumor marker in ovarian carcinoma.

Thirty-three healthy women (group 1), 20 patients with a history of ovarian carcinoma but no manifest disease at the time of the study (group 2), and 45 patients with surgically demonstrable ovarian cancer (group 3) were studied to establish guidelines for the use of the ovarian cancer antigen Ca 125 in monitoring the course of ovarian carcinoma. Ninety-nine percent of all Ca 125 titers of patients in groups 1 and 2 were less than or equal to 25 U/mL. By contrast, 96% of patients with manifest ovarian cancer had Ca 125 levels greater than 25 U/mL.

Genital condylomas in immunosuppressed women: a therapeutic challenge.

Of 30 immunosuppressed women with genital condylomas, 20 (67%) had associated neoplasia of the lower genital tract. We retrospectively studied 11 patients with flat condylomas confined to the cervix; all lesions were eradicated by conventional therapy. Three patients studied retrospectively and 16 studied prospectively had condylomatous lesions involving several sites within the lower genital tract.

[Clinical and mammographic late results following Strömbeck breast reduction-plasties].

Report about 197 breast reductions on 100 patients which were operated by the method of Strömbeck. Indication was mostly macromasty and excessive ptosis. In the mean 740 g were removed on each side, in 18.

[Functional results following conservative and surgical therapy of pathologic fractures in malignant diseases].

From 1972-1982 149 pathological fractures in 91 patients were treated. 134 of these were caused by malignant disease. With 78% metastases were the most common cause for fractures.

A simplified technique for intestinal reanastomosis after the Hartmann procedure.

The technique described herein is simple, fast and provides a secure anastomosis. Mobilization and extensive dissection of either the Hartmann pouch or the stump of the sigmoid colon is avoided. In addition, there is no need for pursestring sutures, which may be difficult to place in patients with short rectal stumps.

Cis-platinum, doxorubicin, and methotrexate treatment for recurrent cervical cancer.

A combination of cis-platinum, doxorubicin (Adriamycin), and methotrexate was used to treat 28 patients with recurrent cervical cancer. Seven patients achieved a partial response with a median duration of ten months. Two patients achieved a complete response with a median duration of 14 months.

Native-like folding intermediates of homologous ribonucleases.

The mechanism of the slow refolding reactions of four different pancreatic ribonucleases from ox, sheep, red deer, and roe deer has been investigated. Refolding kinetics of these proteins were very similar. In particular, a native-like intermediate, IN, was shown to be populated on the slow refolding pathway of all ribonucleases.

The CO2 laser for recurrent and therapy-resistant condylomata acuminata.

The medical records of 48 patients who underwent laser vaporization of therapy-resistant or recurrent condylomata acuminata were studied with regard to history of immunosuppression, location of original lesion, type and duration of therapy, and whether magnification devices were used prior to or during therapy. The genitalia of the patients' sexual partners were examined in all cases in which the condylomata recurred after initial control of the lesions with conventional methods. In 46 of the 48 cases, possible reasons for the failure of conventional therapy could be found: unresponsive to chemical therapy (11 patients); reinfection by the sexual partner (4); immunosuppression (8); several factors (6); and incomplete eradication of the lesion (20).

Combination antiemetic therapy in cisplatin-induced nausea and vomiting.

Twenty-seven consecutive patients with advanced gynecologic malignancies undergoing chemotherapy with cisplatin in combination with other agents were studied in a prospective, randomized fashion to compare the antiemetic efficacy of a combination regimen with high-dose metoclopramide. The combination regimen consisted of prochlorperazine, dexamethasone, and pentobarbital. Patients treated with the combination regimen had significantly less vomitus (P less than 0.

Endocervical curettage after cryotherapy for cervical intraepithelial neoplasia.

Two hundred forty-five patients were studied prospectively to determine the value of endocervical curettage (ECC) in the follow-up of patients having undergone cryotherapy for cervical intraepithelial neoplasia (CIN). Patients at high risk of treatment failure were divided into three groups: (I) CIN grade 3 lesions confined strictly to the ectocervix (86 patients), (II) CIN grade 1-3 lesions involving the endocervix to a depth of up to 5 mm and a negative ECC prior to cryotherapy (64 patients), and (III) CIN grade 1-3 lesions confined to the ectocervix or extending into the endocervix to a depth of up to 5 mm and a positive ECC (27 patients). A fourth group, 68 patients with CIN grade 1 and 2 lesions confined to the ectocervix, was considered to be at low risk of treatment failure and served as controls.

Decreased serotonin content of embryonic raphe neurons following maternal administration of p-chlorophenylalanine: a quantitative immunocytochemical study.

Previous studies from this laboratory have suggested that serotonergic (5-HT) neurons may influence the differentiation of their embryonic target cells in the developing rat brain. The present study was designed to determine whether or not maternal p-chlorophenylalanine (pCPA) administration could deplete serotonin (5-HT) in developing 5-HT neurons during embryonic days 13-15, when the effects of pCPA on neuronal genesis have been observed previously. For this study, pCPA was administered to timed-pregnant rats and embryos were sacrificed at two different gestational ages, embryonic days 13-14 (E13-14) and 14-15 (E14-15).

Uterine sarcoma: analysis of prognostic variables in 71 cases.

The histories of 94 patients with a diagnosis of uterine sarcoma, treated from 1962 to 1982, at the Medical College of Virginia Hospital were reviewed. Histologic features were studied by one of the authors (V.S.

Partial trachelectomy in the elderly patient with abnormal cytology.

Because of an unsatisfactory colposcopic examination, cold knife conization of the cervix is frequently required for the evaluation of postmenopausal patients with abnormal cervical cytology. With advancing age, the cervix atrophies and retracts so that conization becomes increasingly difficult and results in a tissue specimen that is frequently inadequate. Dissatisfied with the results of the standard conization procedure, the authors performed partial trachelectomy in 26 elderly patients with atrophic, retracted cervixes.

Incisional bladder hernia and urinary incontinence: report of three cases.

Herniation of the bladder has been primarily described in association with inguinal and femoral hernias. Review of the literature yielded only one case report of incisional bladder hernia. The authors report three cases of herniation of the bladder through a postoperative fascial defect.