Detainer Requests Issued by ICE and Fair/Poor Self-Rated Health among Latines in the U.S., 2017-2020.

U.S. Immigration and Customs Enforcement (ICE) issues detainer requests to local law enforcement agencies to hold detainees suspected of being undocumented immigrants until they can be transferred into ICE custody.

ICE Detainer Requests Were Associated With Lower Medicaid And SNAP Enrollment Among Eligible Adults, 2011-19.

Legislative policies that criminalize immigrants have a "chilling effect" on public program participation among eligible immigrants. However, little is known about the effect of local enforcement actions by Immigration and Customs Enforcement (ICE). In this study, we linked county-level data on the number of detainer requests (or immigration holds) issued by ICE to individual-level data from the 2011, 2016, and 2019 American Community Surveys.

Participatory Systems Thinking to Elucidate Drivers of Food Access and Diet Disparities among Minoritized Urban Populations.

The purpose of this study was to use participatory systems thinking to develop a dynamic conceptual framework of racial/ethnic and other intersecting disparities (e.g., income) in food access and diet in Philadelphia and to identify policy levers to address these disparities.

Impact of county and state immigration policies on immigrant household enrollment in the supplemental nutrition assistance program.

Introduction: Low-income immigrants who are eligible to participate in the Supplemental Nutrition Assistance Program (SNAP) participate at lower rates compared to non-immigrants. Immigrant households may be more likely to participate in SNAP if they live in areas with policies that integrate them into society and protect them from deportation.

Methods: Data on low-income immigrant households came from the 2019 American Community Survey ( = 87,678).

Epigenetic markers and therapeutic targets for metastasis.

The last few years have seen an increasing number of discoveries which collectively demonstrate that histone and DNA modifying enzyme modulate different stages of metastasis. Moreover, epigenomic alterations can now be measured at multiple scales of analysis and are detectable in human tumors or liquid biopsies. Malignant cell clones with a proclivity for relapse in certain organs may arise in the primary tumor as a consequence of epigenomic alterations which cause a loss in lineage integrity.

Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.

The brain is a major sanctuary site for metastatic cancer cells that evade systemic therapies. Through pre-clinical pharmacological, biological, and molecular studies, we characterize the functional link between drug resistance and central nervous system (CNS) relapse in Epidermal Growth Factor Receptor- (EGFR-) mutant non-small cell lung cancer, which can progress in the brain when treated with the CNS-penetrant EGFR inhibitor osimertinib. Despite widespread osimertinib distribution in vivo, the brain microvascular tumor microenvironment (TME) is associated with the persistence of malignant cell sub-populations, which are poised to proliferate in the brain as osimertinib-resistant lesions over time.

A Precise Cdk Activity Threshold Determines Passage through the Restriction Point.

At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed as a point in G1 that is passed when growth factor signaling initiates a positive feedback loop of Cdk activity. However, recent studies have cast doubt on this model by claiming R occurs prior to positive feedback activation in G1 or even before completion of the previous cell cycle.

Neural correlates of bimodal speech and gesture comprehension.

The present study examined the neural correlates of speech and hand gesture comprehension in a naturalistic context. Fifteen participants watched audiovisual segments of speech and gesture while event-related potentials (ERPs) were recorded to the speech. Gesture influenced the ERPs to the speech.

The Duffy blood group system in Israeli Jews and Arabs.

The distribution of the Fy gene was studied in 1,207 Israeli Jews and 509 Arabs. The Fy(a--b--) phenotype (FyFy) was observed in Moslem, Christian and Druze Arabs, and in Jewish immigrants from Yemen and Iraq, but not in Sephardi or Ashkenazi Jews. The Fy gene frequencies in Arabs and Jews were compatible with historical evidence of interactions with native African and admixed regional populations.