Fast barrier-free switching in synthetic antiferromagnets.

We analytically solve the Landau-Lifshitz equations for the collective magnetization dynamics in a synthetic antiferromagnet (SAF) nanoparticle and uncover a regime of barrier-free switching under a short small-amplitude magnetic field pulse applied perpendicular to the SAF plane. We give examples of specific implementations for forming such low-power and ultra-fast switching pulses. For fully optical, resonant, barrier-free SAF switching we estimate the power per write operation to be  pJ, 10-100 times smaller than for conventional quasi-static rotation, which should be attractive for memory applications.

A Single-Center Experience: Integrated Management in Primary Central Nervous System Lymphoma.

The present study reports a single-center experience conducted at Józef Struś Multispecialty City Hospital in Poznań, Poland, in diagnosing and treating two patients with primary central nervous system lymphoma (PCNSL), one immunocompetent and one immunodeficient (AIDS). PCNSL is an extremely rare neoplasm with a poor prognosis and non-specific treatment on the basis of immunocompetency. Standard treatment consists of high-dose methotrexate (HD-MTX) being the background of a multimodal therapy, including other chemotherapeutic agents with and without radiation.

Molecular and Clinical Features of Pancreatic Acinar Cell Carcinoma: A Single-Institution Case Series.

Acinar cell carcinoma (ACC) accounts for about 1% of pancreatic cancers. The molecular and clinical features of ACC are less characterized than those of pancreatic ductal adenocarcinoma. : We retrospectively evaluated the clinical and molecular features of ACC patients who underwent germline and/or somatic molecular testing at The University of Texas MD Anderson Cancer Center from 2008 to 2022 and two cases from 2023-2024 who underwent RNA and TME analysis by Boston Gene.

Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma.

Background & Aims: The complex tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) has hindered the development of reliable predictive biomarkers for targeted therapy and immunomodulatory strategies. A comprehensive characterization of the TME is necessary to advance precision therapeutics in PDAC.

Methods: A transcriptomic profiling platform for TME classification based on functional gene signatures was applied to 14 publicly available PDAC datasets (n = 1657) and validated in a clinically annotated independent cohort of patients with PDAC (n = 79).

Involvement of UV-C-induced genomic instability in stimulation рlant long-term protective reactions.

The study of the mechanisms affecting single stress factor impact on long-term metabolic rearrangements is necessary for understanding the principles of plant protective reactions. The objective of the study was to assess the involvement of UV-C-induced genomic instability in induction рlant long-term protective reactions. The study was carried out on two genotypes of chamomile, Perlyna Lisostepu (PL) variety and its mutant, using UV-C pre-sowing seed radiation exposure at dose levels 5-15 kJ/m.

Microbiome-preserving antibiotics for the treatment of Clostridioides difficile infection: a systematic review and meta-analysis.

Background: Newer antibiotics that specifically target Clostridioides difficile while preserving the host microbiome have emerged to treat C. difficile infection (CDI): cadazolid, fidaxomicin, ridinilazole, and surotomycin. The aim of the present study was to perform a systematic review and meta-analysis of efficacy for each antibiotic.

Relationship of radiation-induced genomic instability and antioxidant production in the chamomile plant.

Purpose: To verify the hypothesis about the preservation of signs of radiation-induced genomic instability at the flowering stage of the chamomile plant after pre-sowing seed irradiation, the interaction of dose-dependent changes in the level of DNA damage and stimulation of antioxidant production.

Materials And Methods: The study was carried out on two genotypes of chamomile, Perlyna Lisostepu variety and its mutant, using pre-sowing seed radiation exposure at dose levels 5-15 Gy. Studies of the rearrangement of the primary DNA structure of under different doses were studied on plant tissues at the flowering stage using - ISSR and RAPD DNA markers.

Proximity-enhanced magnetocaloric effect in ferromagnetic trilayers.

The demagnetization and associated magnetocaloric effect (MCE) in strong-weak-strong ferromagnetic trilayers, upon a reorientation of the strong ferromagnets from parallel to antiparallel (AP) magnetization, is simulated using atomistic spin dynamics. The simulations yield non-trivial spin distributions in the AP state, which in turn allows entropy to be calculated directly. The influence of longer-range spin-spin interactions and of variable strength of the external switching field are investigated.

Effects of genomic instability in populations of from regions of Ukraine with different impact of radiation factors.

Purpose: To investigate differences in the gonadal dysgenesis frequency as one of the indicators of genome instability through natural populations , selected from Ukrainian regions with different radiation impacts. Follow-up study of the dynamics of this indicator under chronic exposure in laboratory conditions for 10 generations.

Materials And Methods: The study was conducted in two stages.

Epigenetic factors of individual radiosensitivity and adaptive capacity.

Studying the relationship between epigenetic variability with different individual radiosensitivity and adaptive capacity. Using a simple and convenient experimental model - maize seedlings with different germination terms and epigenetic patterns - the hypothesis was tested that homogeneous genetically but epigenetic different organisms have different radiosensitivity and radioadaptive capacity. Differences in the DNA methylation profiles of individual subpopulations of seedlings were used as a marker of epigenetic differences and the yield of chromosomal aberration was used as an indicator of DNA vulnerability and its changes under different UV-C irradiation modes.

Author Correction: Transcriptional Regulation on Aneuploid Chromosomes in Diverse Candida albicans Mutants.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Correction to: Topical antimicrobial prophylaxis in colorectal surgery for the prevention of surgical wound infection: a systematic review and meta-analysis.

Unfortunately, an author name (Nuzhat Iqbal) was missed out in the original publication. The complete updated author list is given below.

Magnetic Hysteresis in Nanostructures with Thermally Controlled RKKY Coupling.

Mechanisms of the recently demonstrated ex-situ thermal control of the indirect exchange coupling in magnetic multilayer are discussed for different designs of the spacer layer. Temperature-induced changes in the hysteresis of magnetization are shown to be associated with different types of competing interlayer exchange interactions. Theoretical analysis indicates that the measured step-like shape and hysteresis of the magnetization loops is due to local in-plane magnetic anisotropy of nano-crystallites within the strongly ferromagnetic films.

Topical antimicrobial prophylaxis in colorectal surgery for the prevention of surgical wound infection: a systematic review and meta-analysis.

Background: Among the techniques investigated to reduce the risk of surgical wound infection or surgical space infection (SSI) in patients having colorectal surgery are topical application of antimicrobials (antibiotics and antiseptics) to the open wound or immediately after closure. The aim of the present study was to perform a systematic review of the literature on those treatments, with the exception of antibiotic ointments applied to closed skin, which are adequately assessed elsewhere, and a meta-analysis.

Methods: Only randomized trials of patients having only colorectal surgery were included in this review.

Transcriptional Regulation on Aneuploid Chromosomes in Divers Candida albicans Mutants.

Candida albicans is a diploid fungus and a predominant opportunistic human pathogen. Notably, C. albicans employs reversible chromosomal aneuploidies as a means of survival in adverse environments.

Correction to: NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins.

After the publication of this work [1], it was noticed that an initial was missing from the author name: Jeffrey Hayes. His name should be written as: Jeffrey J. Hayes.

NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins.

Background: The major human fungal pathogen Candida albicans possesses a diploid genome, but responds to growth in challenging environments by employing chromosome aneuploidy as an adaptation mechanism. For example, we have shown that C. albicans adapts to growth on the toxic sugar L-sorbose by transitioning to a state in which one chromosome (chromosome 5, Ch5) becomes monosomic.

Quantifying annual internal effective Cesium dose utilizing direct body-burden measurement and ecological dose modeling.

The Chernobyl Nuclear Power Plant (CNPP) accident represents one of the most significant civilian releases of Cesium (Cs, radiocesium) in human history. In the Chernobyl-affected region, radiocesium is considered to be the greatest on-going environmental hazard to human health by radiobiologists and public health scientists. The goal of this study was to characterize dosimetric patterns and predictive factors for whole-body count (WBC)-derived radiocesium internal dose estimations in a CNPP-affected children's cohort, and cross-validate these estimations with a soil-based ecological dose estimation model.

Spin dynamics in a Curie-switch.

Ferromagnetic resonance properties of F1/f/F2/AF multilayers, where weakly ferromagnetic spacer f is sandwiched between strongly ferromagnetic layers F1 and F2, with F1 being magnetically soft and F2-magnetically hard due to exchange pinning to antiferromagnetic layer AF, are investigated. Spacer-mediated exchange coupling is shown to strongly affect the resonance fields of both F1 and F2 layers. Our theoretical calculations as well as measurements show that the key magnetic parameters of the spacer, which govern the ferromagnetic resonance in F1/f/F2/AF, are the magnetic exchange length (Λ), effective saturation magnetization at T  =  0 (m0) and effective Curie temperature (T(C)(eff)).

[Fractionated UV-C irradiation effects on the changes of transcribed and satellite DNA methylation profile and unstable chromosomal aberration yield].

Interaction between changes of functionally different DNA methylation pattern and chromosomal aberration yield under fractionated UV-C exposure at the doses-of 6.2-9 kJ/m2 have been investigated. Two ways of meristematic tissue renewal after irradiation have been revealed on the grounds of statistical analysis.

[The effect of epigenetic polymorphism of corn seeds on their germination rate and resistance of seedlings under UV-C exposure].

The hypothesis on connection between various germination rates of seeds that are not in dormancy with their epigenetic polymorphism has been checked. It was shown that seedlings which were characterized with different germination rates had different methylation patterns of transcribed and satellite DNA. Different cytogenetic characteristics and their changes were observed under UV-C irradiation as well.

Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization.

Candida albicans, a fungus that normally inhabits the digestive tract and other mucosal surfaces, can become a pathogen in immunocompromised individuals, causing severe or even fatal infection. Mechanisms by which C. albicans can evade commonly used antifungal agents are not fully understood.

Rotatable magnetic anisotropy in Si/SiO2/(Co2Fe)(x)Ge(1-x) Heusler alloy films.

Polycrystalline (Co2Fe)(x)Ge(1-x) Heusler alloy films are fabricated by sputtering on amorphous substrates and shown to possess three types of magnetic anisotropy. The nearly stoichiometric composition of x = 50 m.f.