Employment of young people with disabilities: The potential of social partnership of universities, municipalities and the labor market of Ukraine.

Background: This study analyzed the existing global experience of university and labor market partnerships concerning the employment of youth with disabilities. It was found that current cooperation models are implemented locally, in a fragmented manner, and are limited to interactions between universities and large enterprises.

Objective: The research aimed to explore the current state of meeting the needs of students with disabilities in terms of providing educational services and employment opportunities and to analyze the interaction between universities, municipalities, and the labor market to improve employment opportunities for young people with disabilities.

[Depressive disorders in adolescents in outpatient psychiatric practice].

Objective: To clarify the clinical features of depressive states in adolescent boys and girls (taking into account age and sex) seeking help from primary care specialists in outpatient psychiatric care.

Material And Methods: The study included 158 patients (89 boys and 69 girls), aged 15-17, with depressive pathology of various genesis, observed in the adolescent office of one of the Moscow psychoneurological dispensary in 2015-2020. The main research methods were clinical-psychopathological, clinical-follow-up, statistical.

"Maybe in a few years I'll be able to look at it": a preliminary study of documentary issues in the Ukrainian refugee experience.

Following the February 2022 invasion of Ukraine by Russia, millions of refugees have fled Ukraine for safety in neighbouring countries, including Poland. This movement of people has been facilitated by, and has produced, documentation that will have significant afterlives as evidence and memory. The records refugees have carried with them, the records they have made during flight, and the records created in their encounters with states and communities beyond their homeland, will be important in the prosecution of war crimes, the reconstruction of events, the reconstitution of communities and the protection of rights and entitlements.

[COVID-TECH AND DIGITAL TECHNOLOGIES IN FOREIGN AND RUSSIAN HEALTH CARE DURING THE NEW CORONAVIRUS INFECTION PANDEMIC].

The novel coronavirus infection (COVID-19) pandemic has become the biggest challenge to global and national health systems in the last 100 years. At the same time, the rapid spread of COVID-19, which required the introduction of quarantine measures, the need to maintain social distance and isolate the infected, spurred the development of information technology (IT). In healthcare, information technology has begun to play the role of support systems for various types of medical activities that have experienced a tremendous increase in workload.

Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose-Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model.

Cysteine proteases obtained from the stem of pineapple or papaya latex, bromelain and papain, respectively, exhibit a broad spectrum of beneficial effects on human health. However, their effects on gut microbiota composition or dose-manner effects on the intestinal integrity of healthy tissue have not been evaluated. In this study, C57BL/6 young, healthy mice were fed bromelain or papain in a dose of 1 mg per animal/day for three consecutive days, followed by the assessment of digestive protein capacity, intestinal morphology and gut microbiota composition.

[Data from the Russian Severe Asthma Registry (RSAR)].

Aim: Creation of the "Russian register of patients with severe asthma" and obtaining data on the population characteristics of patients with severe asthma (SA), the prevalence of SA phenotypes, treatment outcomes and the degree of disease control.

Materials And Methods: Observational non-interventional study, which consists in the data analysis obtained on the basis of registration cards of the Russian Register of Patients with Severe Bronchial Asthma, data collection in which was carried out on the Oracle XE platform. Statistical data processing was carried out using Power BI, PSPP and Microsoft Excel spreadsheets.

[Long-term follow-up study of post-COVID-19 patients].

Aim: To evaluate dynamic changes in the lungs, hemostasis system, immune system in different terms after coronavirus pneumonia.

Materials And Methods: Ventilation-perfusion single-photon emission computed tomography/computed tomography (CT), functional methods of lung investigation, evaluation of hemostasis system, immune status and specific humoral immune response were performed and evaluated in different terms after coronavirus pneumonia. A total of 71 patients were examined according to this protocol.

Identification of Nordic Berries with Beneficial Effects on Cognitive Outcomes and Gut Microbiota in High-Fat-Fed Middle-Aged C57BL/6J Mice.

High-fat diets are associated with neuronal and memory dysfunction. Berries may be useful in improving age-related memory deficits in humans, as well as in mice receiving high-fat diets. Emerging research has also demonstrated that brain health and cognitive function may be related to the dynamic changes in the gut microbiota.

A Metric Test for Assessing Spatial Working Memory in Adult Rats following Traumatic Brain Injury.

Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due to the ethical limitations of human studies, animal models provide suitable alternatives to test treatment methods, and to study the mechanisms and related complications of the condition. Experimental rodent models have historically been the most widely used due to their accessibility, low cost, reproducibility, and validated approaches.

Engaging people who inject drugs and their peers in HIV testing and harm reduction in Ukraine: do they make a difference?

Introduction: People Who Inject Drugs (PWID) should be offered HIV-testing and harm reduction services. We assessed the effectiveness of including PWID and their peers in HIV-testing by comparing for a period before (2013-2014) and after their introduction (2015-2017), the a) numbers HIV tested b) number enrolled in harm reduction and c) frequency of HIV-testing.

Methodology: An analysis of programme data involved PWID aged ≥ 14 years (1st January 2013-31st December 2017) in Ukraine.

Linking intravenous drug users to treatment through non-governmental organizations in Ukraine: how well is it working?

Introduction: Alliance for Public Health, the International Charitable Foundation, coordinates HIV prevention in Non-Governmental Organizations (NGO) working with people who inject drugs (PWID) in Ukraine. We aimed to describe the performance of the differential model of linking PWID to HIV care and treatment (Community Initiated Treatment Intervention - CITI).

Methodology: A retrospective cohort study using routine program data was conducted among 8,927 PWID who were tested positive for the first time during January 2016 - June 2017.

Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission.

Viral hepatitis is a major public health threat and a leading cause of death worldwide. Annual mortality from viral hepatitis is similar to that of other major infectious diseases such as HIV and tuberculosis. Highly effective prevention measures and treatments have made the global elimination of viral hepatitis a realistic goal, endorsed by all WHO member states.

Sources of inflow and nature of redistribution of Sr in the salt lakes of the Crimea.

At the first time for the period after the Chernobyl NPP accident the nature of the redistribution of the Sr concentrations in components of the ecosystems of the salt lakes of the Crimea were identified and described. Concentration of Sr in water of the salt lakes depends on the sources of the inflow this radionuclide into aquatic ecosystems and salinity level of lakes water. Until April 2014 the flow of the Dnieper river water through the Northern-Crimean canal was more important factor of contamination of salt lakes of the Crimea by Sr, than atmospheric fallout of this radionuclide after the Chernobyl NPP accident.

Hepatitis C in Eastern Europe and Central Asia: a survey of epidemiology, treatment access and civil society activity in eleven countries.

Introduction: The 16 countries of the Eastern Europe and Central Asia (EECA) region are home to 6.6 million people in need of treatment for chronic hepatitis C virus (HCV) infection. Because of transformational change in HCV treatment, global efforts to address HCV are accelerating.

The influence of immunoglobulin class G from blood plasma of patients with stroke on the activity of some parameters of hemostasis system.

Today, cardiovascular diseases are one of the main causes of disability of the population. Most of the illnesses, including stroke, are accompanied by the appearance immunoglobulin G (IgG) in the blood circulation. According to the literature sources and previous experiments, it is known that IgG made influence on the hemostasis system.

INDICATORS OF HUMORAL IMMUNITY UNDER CHEMICAL BURNS OF ESOPHAGUS IN RATS.

It is well known that the immune system has been actively involved in the regeneration and healing processes of post burn wounds. However, unanswered questions remain concerning the role of humoral immunity in the healing mechanisms and development of burn wound complications. We have developed an experimental model of chemical esophageal burn (CEB) which corresponds to esophageal burn in 1-8 years old children.

[Ambient air pollution in the city of Irkutsk by emissions from mobile sources (the use of the computational method)].

In the article there are presented the results of calculations of a number of emissions of pollutants from motor vehicles in two districts of the city of Irkutsk. It was revealed that with the change in the structure and intensity of road traffic flows on highways of the city, there is altered the composition and quantity of pollutant emissions, tropic to the respiratory system of the human body. That is of great importance, because in the city of Irkutsk the rate of morbidity and mortality from respiratory diseases is higher than in average in Russia.

[EFFICACY OF DIFFERENT FORMS OF LOCAL HEMOSTATIC MATERIALS BASED ON OXIDIZE CELLULOSE IN THE EXPERIMENT].

The bleeding of intraoperative period is one of the actual problem in surgery. There aren't any universal hemostatic means in spite of large variety of modern hemostatic methods. An experimental research studied the results of hemostatic activity of different forms of materials on the basis of oxidize cellulose (a gauze, a powder) as compared with their foreign analog (a hemostatic gauze "SurgiceI").

[Cyclooxigenase-1 gene polymorphism and aspirin resistance].

The literature data concerning structure of cyclo-oxigenase-1--the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.

[The role of PPARs and their isoforms in metabolic disorders related to insulin resistance and diabetes].

PPARs play the key role in energy homeostasis, inflammation, development of insulin resistance, metabolic syndrome, therefore the special attention is spared to synthesis of the ligand PPARs (fibrates, thiazolidinediones). Three isoforms of PPARs are activated by the fatty acids and their derivatives - eukosanoides. Polymorphism of the Pro 12Ala gene PPARG2 affects the sensitiveness of tissues to insulin and the risk of the development diabetes.

[Regulation of endothelial NO-synthase expression and vascular endothelium dysfunction in cardiovascular pathology].

Nitric oxide (NO) is synthesized from 1-arginine by endothelial nitric oxide synthase (eNOS). NO participates in regulation of physiologically important cardiovascular functions (contractive reduction of heart, cellular proliferation, a tone of vessels and blood pressure), immunity, and nervous systems. Inflammation factors, hypoxia, lipids affect NO synthesis.

Antiaggregant effects of biogenic chloramines.

Alanine and taurine sharply potentiate antiaggregant effects of hypochlorite on platelets in platelet-rich plasma. This effect is determined by more pronounced action of chloramine derivatives, products of interaction of added amino acids with hypochlorite. Platelets are more sensitive to the inhibitory effects of amino acid chloramine derivatives (biogenic chloramines) compared to erythrocytes and neutrophils.

[Initial selectivity of the antiplatelet covalent action of biogenic chloramines on platelet-rich plasma].

To describe in full the peculiarities of the antiplatelet action of covalent inhibitors on platelet-rich plasma, we have proposed to take into account the initial selectivity that determines the elevated efficacy of inactivation of platelet molecular target (receptor). The quantitative index of initial selectivity is the ratio of rate constant of inactivation of the platelet molecular target to the rate constant of the chemical reaction of an inhibitor with reactive atomic groups in plasma proteins. For the important case of the domination of the inhibitor expenditure in the reaction with plasma proteins, a formula was derived which depicts the dependence of the share of inactivated targets on the concentration of the inhibitor introduced and reactive atomic groups contained in plasma.