Production of the Key Immunoregulatory Cytokines and the Content of FoxP3 T-Regulatory Lymphocytes in the Epicardial and Thymus Adipose Tissue in Patients with Coronary Heart Disease.

FoxP3 T-regulatory (Treg) lymphocytes and cytokine production by cells from the stromal vascular fraction (SVF) of epicardial (EAT) and thymus (TAT) adipose tissue of 42 patients with chronic coronary heart disease (CHD) were studied. In the SVF of TAT in patients with Gensini Score (GS)≥74 (the most severe atherosclerosis), the production of IL-1β, TNF, IL-4, and IFNγ was higher, while FoxP3 translocation into the nucleus was lower than in patients with GS<74. The GS index directly correlated with the production of IL-4, IL-1β, and TNF by cells of the SVF of TAT, and inversely - with the production of TNF, IL-17, and IL-10 by cells of the SVF of EAT.

Ecological and health risk assessments of heavy metal contamination in soils surrounding a coal power plant.

Coal combustion at power plants is a significant source of environmental pollution, with the deposition of heavy metals in soils leading to extensive ecosystem contamination and exacerbating the harmful impacts of human activities. This study presents a field investigation of heavy metal concentrations in soils around a coal-fired power plant, with monitoring sites located 1.7 to 15.

Effects of pyrolysis conditions on sewage sludge-biochar properties and potential risks based on PAH contents.

Pyrolysis of sewage sludge can significantly reduce industrial waste while producing high-value biochar for soil improvement. This study aimed to evaluate the quality and safety of biochar from sewage sludge under different pyrolysis conditions. Optimal carbonization conditions (700 °C, 60 min, 5 °C/min) were identified by analyzing the physicochemical properties, elemental composition, structural characteristics, and the specific surface area of biochar.

Effect of Flax By-Products on the Mechanical and Cracking Behaviors of Expansive Soil.

Expansive soils, prone to significant volume changes with moisture fluctuations, challenge engineering infrastructure due to their swelling and shrinking. Traditional stabilization methods, including mechanical and chemical treatments, often have high material and environmental costs. This study explores fibrous by-products of flax processing, a sustainable alternative, for reinforcing expansive clay soil.

Deep underground metagenome-assembled genomes from hydrothermal spring.

We report 19 metagenome-assembled genomes from a deep underground microbial community found in mineralized hydrothermal spring in the Baksan Neutrino Observatory tunnel. The community is predominantly occupied by members of Pseudomonadota (Gamma-, Beta-, and Alphaproteobacteria), Planctomycetota, Myxococcota, Nitrospirota, Cyanobacteria, Gemmatimonadota, and Armatimonadota.

Spatiotemporal shifts in humidification zones: assessing climate impact on bioclimatic landscapes.

Climate change is a global problem that is accompanied by the significant changes in humidification conditions in many regions all over the world. The study examined spatiotemporal changes in humidification zones in southern Russia in the period 1961-2020. Humidification zones were determined in accordance with the classification of the Selyaninov hydrothermal coefficient.

Impact of Thermochemical Treatments on Electrical Conductivity of Donor-Doped Strontium Titanate Sr(Ln)TiO Ceramics.

The remarkable stability, suitable thermomechanical characteristics, and acceptable electrical properties of donor-doped strontium titanates make them attractive materials for fuel electrodes, interconnects, and supports of solid oxide fuel and electrolysis cells (SOFC/SOEC). The present study addresses the impact of processing and thermochemical treatment conditions on the electrical conductivity of SrTiO-derived ceramics with moderate acceptor-type substitution in a strontium sublattice. A-site-deficient SrLaTiO and cation-stoichiometric SrPrTiO ceramics with varying microstructures and levels of reduction have been prepared and characterized by XRD, SEM, TGA, and electrical conductivity measurements under reducing conditions.

Ecological and human health impact assessments based on long-term monitoring of soil PAHs near a coal-fired power plant.

The combustion of coal in power plants releases significant amounts of polycyclic aromatic hydrocarbons (PAHs), which are highly toxic and carcinogenic. This study assesses the ecological and human health impacts of PAHs contamination from a coal-fired power plant over 8 years. The monitoring site selection considered the distance from the power plant and the prevailing wind direction in the investigated area.

Ecological consequences of biochar and hydrochar amendments in soil: assessing environmental impacts and influences.

Anthropogenic activities have caused irreversible consequences on our planet, including climate change and environmental pollution. Nevertheless, reducing greenhouse gas (GHG) emissions and capturing carbon can mitigate global warming. Biochar and hydrochar are increasingly used for soil remediation due to their stable adsorption qualities.

Developing tardigrade-inspired material: Track membranes functionalized with Dsup protein for cell-free DNA isolation.

When developing functionalized biomaterials, the proteins from extremophilic organisms, in particular unique tardigrade disordered proteins, are of great value. The damage suppressor protein (Dsup), initially discovered in the tardigrade Ramazzottius varieornatus and found to be an efficient DNA protector under oxidative and irradiation stress, has been hypothesized to possess a good potential for the development of the material, which can isolate cell-free DNA. With this in mind, DNA-nonadsorbing polyethylene terephthalate track membranes have been functionalized using the Dsup protein via covalent bonding with glutaraldehyde.

Effect of wood and peanut shell hydrochars on the desiccation cracking characteristics of clayey soils.

Soil cracking can significantly alter the water and nutrient migration pathways in the soil, influencing plant growth and development. While biochar usage has effectively addressed soil cracking, the feasibility of using less energy-intensive hydrochars in desiccating soils remains unexplored. This study investigates the impact of wood and peanut shell hydrochars on the desiccation cracking characteristics of clayey soil.

A comparative life cycle assessment of recycling waste concrete powder into CO-Capture products.

Waste concrete powder (WCP), a byproduct of construction and demolition (C&D), currently has a low degree of recycling despite its potential for environmentally friendly applications. WCP can serve as a valuable substitute for cement, offering advantages for resource conservation and carbon sequestration. However, there are very few studies that quantitatively assess the environmental impact of incorporating WCP into the circular economy as a secondary material instead of disposing of it.

Influences of phosphorus-modified biochar on bacterial community and diversity in rhizosphere soil.

Root-associated bacteria play a vital role in the soil ecosystem and plant productivity. Previous studies have reported the decline of bacterial community and rhizosphere soil quality in the cultivation of some medicinal plants (i.e.

Search for Evidence of Baryogenesis and Dark Matter in B^{+}→ψ_{D}+p Decays at BABAR.

A new dark sector antibaryon, denoted ψ_{D}, could be produced in decays of B mesons. This Letter presents a search for B^{+}→ψ_{D}+p (and the charge conjugate) decays in e^{+}e^{-} annihilations at 10.58 GeV, using data collected in the BABAR experiment.

Intermediate Monocytes and Circulating Endothelial Cells: Interplay with Severity of Atherosclerosis in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus.

The aim was to investigate the association of monocyte heterogeneity and presence of circulating endothelial cells with the severity of coronary atherosclerosis in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). We recruited 62 patients with CAD, including 22 patients with DM2. The severity of atherosclerosis was evaluated using Gensini Score.

[Justification of the need to introduce an additional criterion to the assessment of the nutrition status of military personnel].

Currently, in accordance with the regulations of the Government of the Russian Federation and the Ministry of Defense of the Russian Federation, the main indicator for assessing nutritional status is the body mass index, which does not take into account the component composition of the body. At the same time, it is necessary to assess in more detail the composition of the body of military personnel, that is, the ratio of its muscle and fat components. of the study is the scientific and methodological substantiation of the need to introduce an additional criterion for assessing the nutritional status of military personnel, that characterize body composition - the body fat percentage.

Precessing jet nozzle connecting to a spinning black hole in M87.

The nearby radio galaxy M87 offers a unique opportunity to explore the connections between the central supermassive black hole and relativistic jets. Previous studies of the inner region of M87 revealed a wide opening angle for the jet originating near the black hole. The Event Horizon Telescope resolved the central radio source and found an asymmetric ring structure consistent with expectations from general relativity.

Effects of phase change material inclusion on reducing greenhouse gas emissions from soil in cold region.

Increased gas emissions from soil into the atmosphere are one form of ecosystem feedback in response to climate change. Soil temperature plays a critical role in the soil emission of carbon dioxide (CO) and nitrous oxide (NO) suggesting that the release of gases can be reduced by regulating soil temperature. This study proposes a green microencapsulated phase-change material (mPCM) as a soil temperature regulator due to its ability to absorb and release heat during temperature phase transition.

The tardigrade Dsup protein enhances radioresistance in and acts as an unspecific repressor of transcription.

The tardigrade-unique damage suppressor protein (Dsup) can protect DNA from ionizing radiation and reactive oxygen species (ROS). In this study, we generated -expressing lines of and demonstrated that Dsup increased the survival rate after γ-ray irradiation and hydrogen peroxide treatment in flies too, but reduced the level of their locomotor activity. The transcriptome analyses of -expressing lines revealed a significant number of DEGs, >99% of which were down-regulated.

[Somatic pathology in elderly and senile persons suffering from Alzheimer's disease and Alzheimer's type dementia.].

In order to study the prevalence of chronic somatic age-associated pathology in elderly and senile people suffering from Alzheimer's type dementia with the presentation of the hypothesis of somatopsychic pathogenetic comorbidity observation and treatment, 217 patients were observed, conditionally divided into 2 comparable groups: with a definitive diagnosis of Alzheimer's disease (n=73) and with so-called Alzheimer's type dementia (n=144). Distinct differences in the variants of comorbid to the selected types of dementia of somatic pathology were determined, which had a negative impact not only in terms of the occurrence of cognitive disorders, but also in the future, during the formation of the most severe variants of dementia. In cases of Alzheimer's disease, pathological processes in the large intestine turned out to be leading, with Alzheimer's type dementia - diseases of the circulatory system and type 2 diabetes mellitus.

Dynamics of carbon dioxide emission during cracking in peanut shell biochar-amended soil.

As a primary source of greenhouse gas emissions and a carbon sink, soil plays a key role in climate regulation. The development of cracks in soil strongly influences CO emissions, and soil amendment with biochar has been shown to reduce cracking. However, the impact of biochar on CO emissions during soil cracking is not well understood.

Association of Epicardial Adipose Tissue Adipocytes Hypertrophy with Biomarkers of Low-Grade Inflammation and Extracellular Matrix Remodeling in Patients with Coronary Artery Disease.

The aim of the study was to compare the morphological features of epicardial adipose tissue (EAT) adipocyte with the circulating inflammatory biomarkers and parameters of extracellular matrix remodeling in patients with coronary artery disease (CAD). We recruited 42 patients with CAD (m/f 28/14) who were scheduled for coronary artery bypass graft surgery (CABG). EAT adipocytes were obtained by the enzymatic method from intraoperative adipose tissue samples.

Modification of Some Structural and Functional Parameters of Living Culture of as the Result of Selenium Nanoparticle Biosynthesis.

Selenium nanoparticles are attracting the attention of researchers due to their multiple applications, including medicine. The biosynthesis of selenium nanoparticles has become particularly important due to the environmentally friendly character of the process and special properties of the obtained particles. The possibility of performing the biosynthesis of selenium nanoparticles via the living culture of starting from sodium selenite was studied.

Cytobacillus pseudoceanisediminis sp. nov., A Novel Facultative Methylotrophic Bacterium with High Heavy Metal Resistance Isolated from the Deep Underground Saline Spring.

In this study, we present the characterization of the BNO1 bacterial strain isolated from the deep subsurface saline spring at the Baksan Neutrino Observatory INR RAS (Kabardino-Balkaria, Russia). The complete genome sequence of the strain BNO1 is 5,347,902 bp, with a GC content 41 and 49%. The cell wall peptidoglycan contains meso-diaminopimelic acid.