Generating Actionable Insights from Patient Medical Records and Structured Clinical Knowledge.

While adherence to clinical guidelines improves the quality and consistency of care, personalized healthcare also requires a deep understanding of individual disease models and treatment plans. The structured preparation of medical routine data in a certain clinical context, e.g.

Dual Implementation Guides in FHIR and CDA.

Background: The Fast Healthcare Interoperability Resources (FHIR) and Clinical Document Architecture (CDA) are standards for the healthcare industry, designed to improve the exchange of health data by interoperability. Both standards are constrained through what are known as Implementation Guides (IG) for specific use.

Objectives: Both of these two standards are widely in use and play an important role in the Austrian healthcare system.

Multi-Perspective Process Mining Interfaces for HL7 AuditEvent Repositories: XES and OCEL.

Background: Medical information systems frequently use event logging, but these logs are not suitable for process mining as they are not logged in a standardized format.

Objectives: Our goal is to enrich medical event logs for use in process mining.

Method: We present an approach to convert events from standards- based repositories into the XES and OCEL formats commonly used in process mining.

How do Android developers improve non-functional properties of software?

Nowadays there is an increased pressure on mobile app developers to take non-functional properties into account. An app that is too slow or uses much bandwidth will decrease user satisfaction, and thus can lead to users simply abandoning the app. Although automated software improvement techniques exist for traditional software, these are not as prevalent in the mobile domain.

Open Infrastructure for Standardization of HL7® FHIR® Implementation Guides in Austria.

Background: HL7 Austria is a non-profit association dedicated to improving electronic data communication and interoperability in healthcare using the HL7 international standards.

Objectives: We aim to provide an open infrastructure to develop, manage, and maintain HL7 FHIR implementation guides.

Methods: We utilize state-of-the-art open-source tooling developed by the FHIR community to support continuous integration.

FHIR2BPMN: Delivering Actionable Knowledge by Transforming Between Clinical Pathways and Executable Models.

Healthcare processes have many particularities captured and described within standards for medical information exchange such as HL7 FHIR. BPMN is a widely used standard to create readily understandable processes models. We show an approach to integrate both these standards via an automated transformation mechanism.

[Beyond Content Alone: What Cancer Patients Consider as Important in Professional Psychosocial Support].

Objective:  In this study we wanted to find out what cancer patients expect from professional psychosocial support.

Methods:  Within a multicenter prospective study, patients were asked about their expectations from professional psychosocial support two years after diagnosis. Using qualitative methods, categories were built from the answers.

Custom wave-shaped CAD/CAM orbital wall implants for the management of post-enucleation socket syndrome.

The satisfactory management of post-enucleation socket syndrome is a major challenge. In addition to enophthalmos and hypophthalmos, the appearance of the supratarsal fold is frequently unsatisfactory. Using a combination of orbital volume reduction by means of custom wave-shaped CAD/CAM implants (1), the implantation of a dermis-fat graft (2), and the fitting of an acrylic eye prothesis (3), an algorithm has been developed that has led to considerable long-term improvements.

Automated Verification of Structured Questionnaires Using HL7.

Informed consent of patients to research studies is a cornerstone to modern healthcare, which has lead to considerable administrative effort. The purpose of this paper is to show how forms and questionnaires and their respective answers can be captured in a standardized, structured way, in order to enable automated verification. The use of the HL7 FHIR resources Questionnaire and QuestionnaireResponse is discussed with respect to the different implementation options of Extensions, POST Interceptors, FHIR Operations, and CDS Hooks.

Socio-economic disparities in long-term cancer survival-10 year follow-up with individual patient data.

Purpose: Reasons for the social gradient in cancer survival are not fully understood yet. Previous studies were often only able to determine the socio-economic status of the patients from the area they live in, not from their individual socio-economic characteristics.

Methods: In a multi-centre cohort study with 1633 cancer patients and 10-year follow-up, individual socio-economic position was measured using the indicators: education, job grade, job type, and equivalence income.

Prefetching of medical imaging data across XDS affinity domains.

Prior studies as well as medical imaging data are crucial for a radiologist to diagnose a patient. In this paper the radiological workflow is analyzed from a patient's perspective in order to gain knowledge on how possible existing prefetching strategies still can be applied in connection with a standardized distributed health information system conforming to architectures defined by IHE and ELGA. As a result an adaption to such architectures is proposed and further evaluated in a testing environment.

Intraoperative imaging with a 3D C-arm system after zygomatico-orbital complex fracture reduction.

Purpose: During the repair of zygomatico-orbital complex (ZMC) fractures, the lateral orbital wall and/or the orbital floor is often reduced by merely reducing the zygoma. Intraoperative 3D imaging can help surgeons decide whether the orbit must be reconstructed as well. The purpose of this study was therefore to assess the usefulness of intraoperative 3D C-arm imaging in evaluating the adequacy of fracture reduction.

1H-pyrrolo[3,2-h]quinoline: a benchmark molecule for reliable calculations of vibrational frequencies, IR intensities, and Raman activities.

Reliable assignment of 55 out of 57 vibrational modes has been achieved for 1H-pyrrolo[3,2-h]quinoline using IR, Raman, and fluorescence spectroscopy combined with quantum chemical calculations. The experiments provided a data set for assessing the performance of different models/basis sets for predicting the vibrational frequencies, as well as IR and Raman intensities for a molecule with 13 heavy atoms. Among six different tested DFT functionals, the hybrid B3LYP used with Pople's split-valence basis sets is suggested as the best choice for accurate and cost-effective IR/Raman spectral simulations.

Predictors of emotional distress in patients with head and neck cancer.

Background: Patients with head and neck cancer are known to be more commonly emotionally distressed than patients with other tumors. This study investigates reasons for this difference.

Methods: Patients in this prospective cohort study included those with head and neck cancer (n = 113) and those with other cancers (n = 1690).

[Psychiatric comorbidities in visceral surgery patients with cancer].

Background: Cancer patients with mental disorders suffer from a decreased quality of life (QoL) and are in need of appropriate treatment.

Methods: A total of 99 cancer patients were interviewed during surgical inpatient treatment with a structured clinical interview for diagnosis of mental disorders (SCID). The QoL and distress were examined prospectively using the validated questionnaires EORTC QLQ-C30 and HADS.

Anxiety and depression in cancer patients compared with the general population.

The objective of this study was to compare the prevalence of anxiety and depression in cancer patients with the prevalence found in the general population, using the Hospital Anxiety and Depression Scale (HADS). Participants were 1529 cancer patients treated between 2002 and 2004 in Germany and 2037 persons from the German general population. In the cancer patients, the risk of psychiatric distress was nearly twice that of the general population.

[Psychosocial support care wanted and actually received by patients with cancer. Gender-specific differences].

Background And Objectives: Professional psychosocial support of patients with cancer is an essential component of the entire process of medical care of these patients. But so far gender specific differences have only rarely been investigated. Yet some studies have suggested that there are differences between male and female patients regarding their psychological burden and their use of psychosocial support facilities.

Hospital anxiety and depression scale cutoff scores for cancer patients in acute care.

The aim of this study was to determine optimal cutoff scores for the Hospital Anxiety and Depression Scale (HADS) when used in evaluating cancer patients in acute care. A total of 689 cancer patients were assessed during their first days of in-patient treatment, using the structured clinical interview for DSM and the HADS. Statistical analysis was performed using ROC curves.

Specific microsolvation triggers dissociation-mediated anomalous red-shifted fluorescence in the gas phase.

Ion-depletion IR spectroscopy has revealed that at least two water molecules are required in complexes with 4-(dimethylamino)benzoic acid methyl ester (DMABME) for anomalous red-shifted fluorescence to occur in the gas phase. Through the use of high-level quantum-chemical calculations, two experimentally observed isoenergetic isomers are assigned to complexes in which a water dimer is hydrogen-bonded either to the carbonyl oxygen of the ester function or to the amino nitrogen. Surprisingly, computed IR spectra reveal that the N-bonded isomer is responsible for the observed red-shifted fluorescence.

Longitudinal analysis of psychiatric morbidity in cancer patients.

Background: About one third of cancer patients suffers from a psychiatric disorder. However, only few studies feature long-term assessment of psychiatric disease in cancer patients, covering a broad range of diagnoses, and employing high-quality instruments.

Patients And Methods: A total of 62 patients underwent assessments during a 3-year follow-up period after initial cancer diagnosis.

Anxiety and depression in patients with prostate cancer and other urogenital cancer: a longitudinal study.

Objective: The aim of this study was to assess the degree and the course of psychological distress (anxiety and depression) in cancer patients and to detect sociodemographic determinants of the scores.

Methods And Materials: Patients with prostate cancer (n = 287) and other urogenital cancer (n = 126) were tested with the Hospital Anxiety and Depression Scale (HADS) at the following time points: at the beginning (T1) and the end (T2) of the treatment in the hospital, 6 months later (T3), and 1 year later (T4).

Results: Anxiety mean scores were highest at the start of the stay in the hospital.

[The impact of parenthood on quality of life of cancer patients].

Objectives: The aim of this study was to examine the impact of parenthood on the quality of life of cancer patients.

Methods: A sample of 246 cancer patients (56% female) with different cancer locations were surveyed at the beginning of their inpatient medical treatment (t1) and 6 months afterward (t2) using the EORTC QLQ-C30 questionnaire. Three subgroups were compared in a cross-section and a longitudinal design.

The Course of Anxiety and Depression in Patients with Breast Cancer and Gynaecological Cancer.

BACKGROUND/AIMS: The aim of this study was to assess the course of anxiety and depression in cancer patients over time and to detect determinants of the changes in the scores. PATIENTS AND METHOD: Women with breast cancer and gynaecological cancer (n = 367) were tested at the beginning (T1) and at the end (T2) of treatment in the hospital, 6 months later (T3), and 12 months later (T4), using the Hospital Anxiety and Depression Scale (HADS). RESULTS: Anxiety and depression were highest at the start of the stay in the hospital.

Long-term course of psychiatric disorders in cancer patients: a pilot study.

Background: About one third of cancer patients suffer from a psychiatric disorder. However, only few studies feature long-term assessment of psychiatric disease in cancer patients, covering a broad range of diagnoses, and employing high-quality instruments.

Patients And Methods: A total of 62 patients underwent assessments during a 3-year follow-up period after initial cancer diagnosis.