Immunization of US soldiers with a two-dose primary series of inactivated hepatitis A vaccine: early immune response, persistence of antibody, and response to a third dose at 1 year.

To study the feasibility of using inactivated hepatitis A vaccine for rapid immunization of US soldiers, 276 randomized seronegative volunteers received one of four regimens: two injections, on day 0 or one each on day 0 and 14, day 0 and 30, or day 0 and 180. A third dose was given on day 380. Among the 256 recipients of two doses, 99% responded with antibody (by ELISA) with few symptoms.

A comparison of coping strategies of aging mothers of adults with mental illness or mental retardation.

Differences in coping by 105 aging mothers of adults with mental illness and 389 similar mothers of adults with mental retardation were investigated. Although no differences in problem-focused coping were found, mothers of adults with mental illness used more emotion-focused coping, which predicted greater maternal depression. For mothers of adults with retardation, depressive symptoms were a function of their child's behavior problems, although this source of stress was buffered by coping.

Effective fragment potentials and spectroscopy at enzyme active sites.

Spectroscopy at a biochemical active site is influenced by local fields and hydrogen-bonds. Quantum calculations of the electronic structure of the entire biomolecule is, of course, impossible, but the chemical system can be modeled by dividing it into an active region (A) described quantum mechanically, and a spectator region (S) that influences A with strong fields and hydrogen-bonds. The all-electron interaction between A and S is replaced by an effective fragment potential (EFP) which represents the interaction as electrostatic, polarization and exchange repulsion terms.

Incorporation of screening echocardiography in the preparticipation exam.

We sought to evaluate the economic aspects and benefits of adding a limited screening echocardiogram to our annual athletic preparticipation examinations. It was our belief that this screening echocardiogram would add valuable information beyond the history and physical exam alone and could be included in our station-by-station format with little increase in time or cost. Controversy exists concerning the best method of detecting cardiovascular conditions that may predispose the athlete to sudden death.

[The quantitative determination of the protein content of milk by means of violet spectral photometry. 7. The milk analyzer MAG 100 (Carl Zeiss Jena GmbH)--a possibility for simultaneous measurement of protein and fat content in raw milk at the dairy farm].

A new analysing apparatus is introduced, which allows to measure protein and fat contents of milk in the dairy farm. The instrument works on the basis of ultraviolet spectral photometry. Before measuring the milk sample must be diluted with a hydrous detergent solution in the ratio 1:100 and then homogenized.

FK 506 versus cyclosporin in the prevention of renal allograft rejection--European pilot study: six-week results.

FK 506 was compared with cyclosporin in a randomised trial in good-risk cadaveric renal transplant recipients. The objective was to evaluate whether oral FK 506 dosing was viable and whether blood concentrations in the range 10-20 ng/ml would prove to be practical. Thirty-one adult patients were randomised to FK 506 and 16 to cyclosporin.

Jejunal obstruction as a late result of neonatal jejunal atresia.

The authors report on two adults who had jejunal dilatation after having had resection for jejunal atresia in the neonatal period. Both patients presented 20 years after the initial procedure, with severe iron deficiency anemia, marked jejunal dilatation proximal to the old anastomotic site (which was not narrowed), and a bezoar within the dilated segment. Upper gastrointestinal series were used to evaluate both patients before surgical resection of the enlarged intestine, with subsequent correction of the anemia.

Development towards multimedia medical workstations.

In this paper, concepts and examples of medical workstations with multimedia and hypermedia capabilities will be presented. These workstations have special hardware and software requirements. Also described in the article are the developments in Europe (AIM project line) within this area.

Dynamic three-dimensional echocardiographic imaging of congenital heart defects in infants and children by computer-controlled tomographic parallel slicing using a single integrated ultrasound instrument.

Three-dimensional cardiac reconstruction generated from transesophageal interrogation can be performed using an integrated unit that captures, processes, and postprocesses tomographic parallel slices of the heart. This probe was used for infants and young children in the transthoracic position to evaluate the feasibility of producing three-dimensional cardiac images with capability for real-time dynamic display. Twenty-two infants and children (range 1 day-3.

A longitudinal tibial stress fracture.

Tibial stress fractures are common in an athletic population. The patient is usually an athlete who is involved in highly repetitive impact activities that have increased in intensity, and who develops pain over the anterior tibia that is felt with exercise and relieved by rest. Physical examination usually reveals focal bony tenderness.

Tetrasomy 8 as a clonal anomaly in myeloid neoplasias.

Tetrasomy of chromosome 8 as a sole anomaly is apparently extremely rare in acute non-lymphocytic leukemia (ANLL): Only two cases have been reported, one of ANLL (M5b) with this karyotype. Very recently, another case was reported of a myelodysplastic syndrome (MDS) with isolated tetrasomy 8. We report tetrasomy 8 in four cases of ANLL, two of them with M5 and one with M1 subtype.

Adults with Down syndrome and their aging mothers: diagnostic group differences.

Adults with Down syndrome (n = 160) and their aging mothers were compared with adults who have mental retardation due to other causes (n = 253) and their mothers in order to determine the nature and direction of diagnostic group differences at the middle and later stages of the family life course. Consistent with research on young families with a child who has Down syndrome, aging mothers of adults with Down syndrome reported less conflicted family environments, more satisfaction with their social supports, and less stress and burden associated with caregiving than did mothers whose adult child's mental retardation was due to other causes. Factors associated with patterns of stability and change in diagnostic group differences were discussed.

Child-related and parenting stress: similarities and differences between mothers and fathers of children with disabilities.

Data concerning similarities and differences in child-related and parenting stress between mothers and fathers of 121 toddlers with disabilities were presented. Fathers reported more stress related to their child's temperament and their relationship to their child. Mothers reported more stress from the personal consequences of parenting.

An outbreak of hepatitis A during a military field training exercise.

Hepatitis A continues to pose a preventable threat to modern day military forces. We describe a food-borne outbreak of hepatitis A during a field training exercise resulting in 22 ill soldiers and over 300 lost work days. Among the population at risk, the secondary attack rate was 19.

Late results of the surgical treatment of complete unilateral cleft lip and palate: soft tissue characteristics.

Sixty-one UCLP patients at 17-20 years of age treated in childhood by the same surgeon (Krauss) were invited for check-up examination to evaluate the late results of the surgical treatment. In the patients, the cleft lip was closed by a modified Le Mesurier procedure at 6-9 months of age and the cleft palate by a modified Veau procedure at 3-4 years of age. The "normal face" appearance showed 69% of the patients.

Induction of leucine aminopeptidase by interferon-gamma. Identification by protein microsequencing after purification by preparative two-dimensional gel electrophoresis.

The protein previously called "Mr approximately 50/pI approximately 6.9," which we observed to be induced by the immunoregulatory cytokine interferon (IFN)-gamma in human fibroblasts, was purified from a total cell lysate by preparative two-dimensional gel electrophoresis and identified by partial amino-terminal sequencing as leucine aminopeptidase (LAP), a 53-kDa cytosolic exopeptidase. Induction of LAP protein by IFN-gamma, confirmed by immunoblotting with an antiserum raised against bovine lens LAP, is a consequence of induction of LAP mRNA and occurs in all four human cell lines examined: HS153 fibroblasts, ACHN renal carcinoma, A549 lung carcinoma, and A375 melanoma.

Attendance and referral patterns in a health promotion program for soldiers.

We studied referral patterns among 505 active duty Army participants in a heath promotion program at Fort Lewis, Washington. Over one-third (35.6%) were referred to health care providers for confirmation of cholesterol or blood pressure screening results.

Social support networks of adults with mental retardation who live at home.

The social support networks of 418 adults with mental retardation who live at home were found to be large, durable, active, and diverse in their composition. Family members predominated as members of these support networks. Differences were found in many network characteristics based on the gender and level of mental retardation of the adults.

Development of infants with disabilities and their families: implications for theory and service delivery.

This Monograph presents the results of a nonexperimental, longitudinal investigation of developmental change in 190 infants and their families after 1 year of early intervention services. The Early Intervention Collaborative Study (EICS), conducted in association with 29 community-based programs in Massachusetts and New Hampshire, was designed to assess correlates of adaptation in young children with disabilities and their families over time, to inform social policy by analyzing the influences of family ecology and formal services on child and family outcomes, and to generate conceptual models to guide further investigation. The study sample (mean age at entry = 10.

Manganese superoxide dismutase is induced by IFN-gamma in multiple cell types. Synergistic induction by IFN-gamma and tumor necrosis factor or IL-1.

We have previously characterized more than 20 proteins induced by the immunoregulatory lymphokine IFN-gamma in human fibroblasts by their m.w. and isoelectric points determined in two-dimensional gels.

[Our experience with reconstruction of the breast].

Breast reconstruction in female patients undergoing mastectomy for breast cancer (17 patients) or benign breast disease (2 patients), and malformation of breast due to asymmetry (19 patients) was started in 1983. Mastectomy in 10 patients was performed because of the cancer, and in 17 patients due to benign breast disease. Age of patients ranged from 15 to 58 years.