Comparison of 99mTc phosphate and diphosphonate complexes in experimental renal infarcts.

The 3-hour biodistribution of 99mTc complexes of five diphosphonates (HMDP, NMMDP, DMAD, DPD, and APD), imidodiphosphonate (IDP), and pyrophosphate (PYP) was compared in rats with segmental renal infarction induced by a 1-hour occlusion of a renal artery branch. 95mTc labeled MDP was a reference substance in all animals. Three agents (APD, HMDP and IDP) had a higher infarct/normal kidney concentration ratio than MDP, the latter two by virtue of a lower content in normal kidney.

The failed penile prosthetic implantation despite technical success.

Successful implantation of a penile prosthesis involves more than an operation. Psychological factors can be crucial before, during and after the operation. If these issues are not addressed the true goal of restoring the pleasure of sexual intercourse will not be achieved, regardless of the type of prosthesis used or the technical success of the procedure.

Transcutaneous electrical nerve stimulator for stress incontinence.

It has been shown that some patients with stress incontinence after prostatectomy may have significant improvement with electrical anal stimulation. The use of a transcutaneous stimulator is the easiest and least invasive method to try initially. Results may be quite satisfying whether the mechanism is physiologic or placebo.

The microgenesis of some renal calculi.

We studied calcium oxalate stone formation in rats in which calculogenesis was induced by a diet deficient in pyridoxine (vitamin B6). We studied the sequence of stone formation using both a gross specimen transillumination technique, which is described, and histologic methods. A characteristic regional distribution of calculi is described and illustrated.

Evidence for a new mammalian organ. IV. Stone formation.

We studied calcium oxalate stone formation in rats after calculogenesis had been induced by a diet deficient in pyridoxine (vitamin B6). Urinary calculi had formed within 6 weeks in 86 per cent of 114 animals. The calcium handling properties of 17 tissues (including the renal sinus "gland") were compared in normal and pyridoxine deficient animals.

Urodynamics of post-radical perineal prostatectomy incontinence.

A series of post-radical perineal prostatectomy patients was studied by carbon dioxide cystometry. Of 30 patients questioned 17 were available for urodynamic assessment. All patients had shortened functional urethral lengths and decreased maximal closure pressures and incontinent patients had changes in the standing position.

Maternal responsiveness of primiparous mothers during the postpartum period: age differences.

Variables influencing maternal responsiveness of primiparous mothers in the postpartum period were explored. Forty mothers, aged 17 to 24, were randomly assigned to either a control group, or to a group with one of two experimental conditions: additional information given mothers about the sensory capacity of neonates, or additional postpartum contact with their infants. Age differences in maternal responsiveness were also examined.

X-linked recessive congenital muscle fiber hypotrophy with central nuclei: abnormalities of growth and adenylate cyclase in muscle tissue cultures.

Muscle cells in cultures established from biopsy specimens of two children with an infantile-fatal form of X-linked recessive muscle fiber smallness with central nuclei showed an unusual ability to proliferate through numerous passages. Ultrastructurally, the cultured muscle fibers appeared very immature even after several weeks. The nuclei were large, the number of ribosomes was greatly increased, the myofibrils remained unstriated, and glycogen was accumulated in large lakes.

Fulminating hypercalcemia and markedly increased nephrogenous cyclic AMP in a patient with transitional cell carcinoma of the bladder.

Refractory hypercalcemia developed suddenly in a patient who had undergone a radical cystectomy for an anaplastic transitional cell carcinoma of the bladder. A normal serum parathyroid hormone (PTH) value was obtained by immunoassay while the patient had hypercalcemia and unimpaired renal function. This normal PTH value in the presence of hypercalcemia was consistent with his hypercalcemia being secondary to excessive amounts of circulating PTH.

Evidence for a new mammalian organ. II. Calcium kinetics.

The calcium content and calcium kinetics of the fatty tissue complex comprising the renal sinus organ of the rat kidney are reported. A comparison is made to control brown and white fat in the same animal. The calcium content of the renal sinus tissue is significantly greater than controls.

Incapacitating flank pain of questionable renal origin.

Local anesthetics can play a significant role in the diagnosis, and possible definitive treatment, of previously intractable flank pain. Numerous patients may thus be spared unnecessary physical and mental anguish, as well as unnecessary surgery.

Evidence for a new mammalian organ. II. Calcium kinetics.

The calcium content and calcium kinetics of the fatty tissue complex comprising the renal sinus organ of the rat kidney are reported. A comparison is made to control brown and white fat in the same animal. The calcium content of the renal sinus tissue is significantly greater than controls.

The benign killer: carcinoma of the prostate.

Radical prostatectomy has a significant role in the treatment of early stage carcinoma of the prostate, with a 6-fold difference in the radically and conservatively treated groups. Since 32 per cent of carcinomas will be missed even by experienced examiners on rectal examination, we believe that open perineal biopsy of the posterior lamella as described in 1968 would increase the yield of carcinoma and the subsequent cure by a radical operation. We have found that older patients do well with the perineal surgery--the extreme lithotomy position is no great problem and the postoperative course, without a painful abdominal wound, is less complicated.