Effects of colchicine on myelination of rabbit optic nerve: a biochemical study.

The effects of intravitreous injections of colchicine on the myelination of the optic nerve were studied in rabbits at different times during development using biochemical and morphological techniques. Myelin basic protein concentrations and 2',3-cyclic nucleotide 3'-phosphodiesterase activities were affected in a similar way by colchicine treatment and reflected the degree of myelination of the tissue. During early development, colchicine produced axonal degeneration and secondary demyelination (Wallerian degeneration).

Myelin proteins, glycoproteins, and myelin-related enzymes in experimental demyelination of the rabbit optic nerve: sequence of events.

Wallerian degeneration of the rabbit optic nerve was investigated by the technique of retinal ablation which precludes edema, hemorrhage, or macrophage infiltration. After 8 days of degeneration, marked degradation of axons and some myelin abnormalities appeared in the optic nerve, optic chiasma, and optic tract. Myelin lesions were maximal 32 days after retinal destruction.

Familial brain tumors: rhombencephalon-astrocytoma grade I in father and son.

This report presents a clinico-pathologic study of low-grade astrocytoma in father and son whose relatives had multiple sclerosis and Cockayne syndrome. The corresponding location within the rhombencephalon and the coincidence of tumor type probably imply that an endogenous genetic factor has influenced the astrocyte cell line.

Intracranial giant cell arteritis.

A case of giant cell arteritis of intracranial vessels diagnosed by autopsy is described. Giant cell arteritis of the proximal basal brain arteries was exceptionally marked in a man of 60 years. The clinical course, laboratory findings and the pathological alterations of the brain and intracranial blood vessels are described.

Oligodendroglioma with a twenty-two year history. Clinicopathological case report.

Clinico-pathologic report of a patient with an oligodendroglioma who ran a 22-year course characterized by focal epileptic seizures of the Jaksonian type. The EEG remained normal for many years. Since the tumor had not been influenced by therapeutic measures, the histologic picture permitted considering some basic problems of origin, growth, and differentiation of oligodendrogliomas.

Kinetic studies on glial, Schwann and capsular cells labelled with [3H] thymidine in cerebrospinal tissue of young mice.

Neuroglia, capsular and Schwann cell renewal and turnover in the cerebellum, the spinal cord and spinal ganglia have been evaluated in 2-months-old mice. The animals received intraperitoneal injections of [3H] thymidine at 8 hr intervals starting on the 28th day of postnatal life for a period of 30 days and were killed 1 hr after the last injection. Substantial numbers of labelled neuroglial cells but no labelled neurons were observed.