One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors.

In Saccharomyces cerevisiae, genes located at the telomeres and the HM loci are subject to transcriptional silencing. Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus.