Tissue transglutaminase and endomysial autoantibodies measured in an historical cohort of children and young adults in whom coeliac disease was suspected.

Objective: To evaluate whether anti-endomysial and anti-transglutaminase antibodies are relevant important markers of coeliac disease in an historical group of patient sera.

Design: Sera from 196 children suspected to suffer from coeliac disease were analysed for these antibodies.

Methods: A total of 233 serum samples were obtained simultaneously with a biopsy.

Treatment of Helicobacter pylori in children with recurrent abdominal pain.

Background: The role of Helicobacter pylori remains unclear in children with recurrent abdominal pain (RAP). In this study children with RAP were included in a double blind treatment study to elucidate whether symptoms disappear in children with a H. pylori infection and RAP, if the bacteria are eradicated.

Different patterns of Helicobacter pylori adherence to gastric mucosa cells in children and adults. An ultrastructural study.

Background: Infection with Helicobacter pylori in childhood may be the initiation of a lifelong coexistence between microorganisms and epithelial cells resulting in chronic inflammation. The adhesion pattern of H. pylori found in antral biopsies from a group of H.

Interobserver variation in diagnosing coeliac disease. A joint study by Danish and Swedish pathologists.

There is an almost 40-fold difference in incidence rates of symptomatic coeliac disease between Denmark and Sweden. In an attempt to explain this difference, the present study focused on the interobserver agreement when pathologists were assessing small intestinal biopsy specimens from children suspected of suffering from coeliac disease. The study was performed on 90 biopsy specimens from 73 children.

[Inflammatory bowel diseases in children].

From an incidence cohort diagnosed during 1962-1987 we identified all patients with onset of IBD before the age of 15 in order to describe the course and to compare course and prognosis with adult onset IBD. The mean incidence of IBD among children below 15 years was 2.2/10(5), 2.

The prevalence and related symptomatology of Helicobacter pylori in children with recurrent abdominal pain.

The aim of the study was to assess and compare the IgG seroprevalence of H. pylori in children with recurrent abdominal pain with healthy children and to investigate the related symptoms. IgG antibodies against low-molecular weight H.

[Pediatric colonoscopy].

The procedure and results of 50 colonoscopies performed over a three-year period on a group of 43 children (range: 0.3-16 yr; median: 9 yr) are described. The main indications were evaluation for, or control of already known, chronic inflammatory bowel disease (n = 38) and rectal bleeding (n = 8).

Abdominal ultrasonography in the diagnostic work-up in children with recurrent abdominal pain.

Unlabelled: We report on our experience with routine abdominal ultrasonography in 120 children (aged 3-15 years) with recurrent abdominal pain, in order to determine the diagnostic value of this investigation. Eight children (7%) revealed sonographic abnormalities: gallbladder stone (n = 2), splenomegaly (n = 1) and urogenital abnormalities (n = 5). The recurrent abdominal pain could be explained by these findings in only two (may be three) cases.

[Esophago-gastro-duodenoscopy of pediatric patients].

In total 199 oesophago-gastro-duodenoscopies (OGD) were performed in 71 female and 71 male paediatric patients (three months-15 years, median 8 years 2 months). The endoscopy was performed in general anaesthesia in children less than five years old, and in an intravenous sedation in older patients. The indications for OGD were: recurrent abdominal pain and concomitant positive antibodies against Helicobacter pylori as a part of a scientific project, upper dyspepsia, upper gastrointestinal bleeding, failure to thrive, coeliac disease, suspicion of chronic inflammatory bowel disease and a percutaneous gastrostomy.

Pancreatitis in a child after rectal administration of 5-aminosalicylic Acid.

: A case of 5-aminosalicylic acid (5-ASA)-induced pancreatitis in a 7-year-old girl with ulcerative colitis is described. Pancreatitis was first diagnosed after 7 months of treatment with 5-ASA by mouth. When she later received 5-ASA rectally, pancreatitis recurred after 2 weeks of treatment.

Inflammatory bowel diseases with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort.

Background And Methods: In a geographically derived incidence cohort diagnosed from 1962 to 1987 we identified all patients with onset of inflammatory bowel diseases (IBD) before the age of 15 years, to describe the clinical course and to compare the course and prognosis with those of adult-onset IBD.

Results: The mean incidence of IBD among children below 15 years was 2.2/10(5), 2.

[Celiac disease in children on the two sides of the Sound].

Of 771 children (381 Swedish and 390 Danish) investigated during 1972-1989 because of suspected coeliac disease (CD), 179 proved to have the disease. Surprisingly only 24 CD patients were Danish whereas 155 were Swedish, despite the very similar ethnic, geographical, and cultural backgrounds of the two populations. The Danish CD children were diagnosed at an older age (mean 5.

Striking differences in the incidence of childhood celiac disease between Denmark and Sweden: a plausible explanation.

Among 771 children (381 Swedish and 390 Danish) investigated between 1972 and 1989 because of suspected celiac disease (CD), 179 proved to have the disease. Surprisingly only 24 CD patients were found among the Danish children, compared with 155 in the Swedish group, despite the close ethnic, geographical, and cultural background of the two populations. The Swedish CD children were diagnosed at an earlier age than the Danish children (mean, 1.

Helicobacter pylori infection in children with recurrent abdominal pain.

Helicobacter pylori was cultured and Helicobacter-like organisms (HLO) were seen in 6 (16%) of 37 children with recurrent abdominal pain. Five children had concomitant histological inflammation, but none had endoscopic changes. All 6 children demonstrated positive serology.

Insulin-like growth factor-I in celiac disease.

To contribute to the description of the physiopathological mechanisms of celiac disease, changes in insulin-like growth factor I (IGF-I) were followed-up in 21 children suspected of suffering from celiac disease. Thirteen children were suffering from celiac disease according to the original criteria of the European Society of Paediatric Gastroenterology and Nutrition. Ten celiac children changing from a gluten-containing to a gluten-free diet presented a significant rise in IGF-I (+1.

The humoral immune response to Helicobacter pylori infection in children with recurrent abdominal pain.

The systemic humoral immune response to Helicobacter pylori antigens was investigated in 36 children with recurrent abdominal pain (RAP). H. pylori was cultured and Helicobacter-like organisms (HLO) were seen in six children, three of whom had active and two inactive chronic gastritis.

[Helicobacter pylori infection in children].

Approximately 10 per cent of all schoolchildren have recurrent stomach pain, and 50 per cent of those referred to hospital for gastralgia can be expected to have persistent problems as adults. Some of these children might be helped by diagnosis and treatment. The lack of large controlled studies of the importance of H pylori in childhood needs to be remedied, with a view to diagnosis and treatment in the future.

[Giardiasis in children with chronic diarrhea. Incidence, growth, clinical symptoms and changes in the small intestine].

During a six-year period, 29 children (aged 0.7-13.5 years, mean 3.

The diagnostic value of the gliadin antibody test in celiac disease in children: a prospective study.

Serum gliadin antibodies (IgA/IgG) were determined in 191 consecutive children (median age, 2.75 years; range, 0.33-15.

Extremely low incidence rates of celiac disease in the Danish population of children.

Incidence rates by birth of celiac disease of 0.09 per 1000 live births were described for the period 1960-88 in the entire Danish population. Broad diagnostic criteria were used in order to prevent the risk of under-diagnosing the disease.

Giardiasis causing chronic diarrhoea in suburban Copenhagen: incidence, physical growth, clinical symptoms and small intestinal abnormality.

During a six-year period, 29 children (aged 0.7-13.5 years, mean 3.

Low incidence rates by birth of symptomatic coeliac disease in a Danish population of children.

Using the original diagnostic criteria of the European Society for Paediatric Gastroenterology and Nutrition for symptomatic coeliac disease in children, we found an average incidence rate by birth of 0.10 per 1000 live births in a demographically homogeneous Danish population over a 15-year period. This incidence rate by birth is the lowest described in an epidemiological study in contrast with rates of 0.