Publications by authors named "Kranti Kamble"
Arch Biochem Biophys
April 2014
Article Synopsis
- Methionine sulfoxide reductase B3 (MsrB3) is an enzyme in the endoplasmic reticulum that reduces methionine-R-sulfoxide back to methionine and plays a significant role in cell proliferation.
- Deleting MsrB3 in mouse embryonic fibroblast (MEF) cells resulted in decreased cell growth and increased levels of the tumor suppressor protein p53, which then raised levels of cell cycle inhibitors p21 and p27, leading to cell cycle arrest in the G1 phase.
- The study shows that MsrB3 is crucial for regulating cell growth by interacting with the p53-p21 and p27 pathways, a finding that was also
