Dysregulation of calcium homeostasis in cancer and its role in chemoresistance.

Globally, cancer, as a major public health concern, poses a severe threat to people's well-being. Advanced and specialized therapies can now cure the majority of people with early-stage cancer. However, emerging resistance to traditional and novel chemotherapeutic drugs remains a serious issue in clinical medicine.

Interplay between dental caries pathogens, periodontal pathogens, and sugar molecules: approaches for prevention and treatment.

Globally, oral diseases affect nearly 3.5 billion people, accounting for 4.6% of the healthcare expenditure.

Antibiotics Knowledge, Usage, and Prescription Patterns Among Dental Practitioners in Hyderabad, South India.

Background: Antimicrobial resistance is a pertinent issue in the healthcare sector, accounting for 1.27 million patient deaths worldwide. Dental practitioners account for 3% to 11% of total antibiotic prescriptions.

Research and therapeutic applications of silk proteins in cancer.

Despite the availability of advanced treatments, cancer remains the second leading cause of death worldwide. This is due to the many challenges prevailing in the research field and cancer therapy. Resistance to therapy and side effects provide major hindrances to recovery from cancer.

Silk Hydrogel for Tissue Engineering: A Review.

Aim: This review aims to explore the importance of silk hydrogel and its potential in tissue engineering (TE).

Background: Tissue engineering is a procedure that incorporates cells into the scaffold materials with suitable growth factors to regenerate injured tissue. For tissue formation in TE, the scaffold material plays a key role.

Age Estimation in Mixed-dentition Children, Using Cameriere's European Formula and Demirjian's Method: A Comparative Pilot Study.

Aim: The objective of the present investigation is to compare the accuracy of two methods of age estimation, Cameriere's European formula and Demirjian's method, in estimating the age of mixed-dentition children in Telangana.

Materials And Methods: Digital orthopantomographs (OPGs) of 36 children between the age of 7 years and 12 years were subject to analysis. All the OPGs were analyzed for dental age using both Cameriere's and Demirjian's methods for mixed dentition.

Estimation of Dental Anxiety Levels Before and After Dental Visit in Children with Visual Impairment Using Modified Dental Anxiety Scale in Braille Text.

Objective: Dental anxiety and fear of dental treatment in special children has been recognized as a public health dilemma. Dental anxiety (being the fear of unknown in a dental setting) would definitely have a substantial effect on the children with visual impairment. Assessment of the dental anxiety makes it possible to design intervention programs aimed at reducing the anxiety levels in children with visual impairment.

A Comparative Study of Shear Bond Strength of Direct Bonding System with and without a Liquid Primer: An Study.

Background: A primer in dental bonding agents enhances the bond between the adhesive and the tooth by way of deriding the tooth surface of moisture and creating a hydrophobic surface for the adhesive to bond and by facilitating the flow of the adhesive into the etched tooth surface. In the orthodontic context, however, there have been debatable results in the published literature as to how significantly the use of primer affects the bond strength between the bracket and the tooth surface.

Aims: This study aimed to evaluate and compare the shear bond strength of two commercially available direct bonding systems with and without using liquid primer and to record their adhesive remnant index scores.

Distribution of Periodontal Pockets Among Smokers and Nonsmokers in Patients with Chronic Periodontitis: A Cross-sectional Study.

Context Cigarette smoking is a well-established risk factor for periodontitis and carries an increased risk for loss of periodontal attachment as well as bone loss. Aims The purpose of the present study was to investigate whether disease severity differs between smokers and nonsmokers in a group of chronic periodontitis patients by assessing the periodontal probing depth (PPD) and bleeding on probing (BOP). Materials and methods The study included 150 individuals, 75 smokers and 75 nonsmokers, in the age group of 35-60 years.

Prevalence of Dental Anxiety Level in 6- to 12-Year- Old South Indian Children.

Background: Dental anxiety is one of the prime reasons for discouraging children to receive dental treatment. Measurement of the dental anxiety is very useful to know the prevalence level among 6- to 12-year-old children. Thus, the aim of the study was to determine the dental anxiety among 6- to 12-year-old children using Modified Dental Anxiety Scale (MDAS) score.

Treatment of Stage I Hard Palate Cancer with High-Dose-Rate Brachytherapy Using Molds: Cost-Based Perspective.

Introduction: Treatment of T1N0M0 (T1 = greatest tumor size < 2 cm, N0 = regional lymph nodes not palpable by clinical examination, M0 = No evidence of distant metastasis) (Green FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, Morrow M. AJCC Cancer Staging Manual. New York: Springer; 2002) lesions of hard palate carcinoma by radiotherapy carries equal results with the advantage of cosmesis and can avoid surgical complications.

Comparative Analysis of Intravenous Midazolam with Nasal Spray for Conscious Sedation in Minor Oral and Maxillofacial Surgeries.

Aim: The aim of the current study was to evaluate the efficacy of nasal spray midazolam by collating it with conventional intravenous midazolam for conscious sedation in minor oral surgeries.

Materials And Methods: Sixty patients were selected randomly and divided into two groups: group A for intranasal midazolam atomized spray ( = 30) and group B for intravenous midazolam ( = 30). Physiological parameters, anxiety score, sedation rating, patient's cooperation score, and retrograde and anterograde amnesia were recorded for each patient during preoperative, intraoperative, and postoperative period.

Knowledge Analysis of Pit and Fissure Sealants among the Dental Students of South India.

Aim: This study aimed to assess the level of knowledge and attitudes for pit and fissure sealants among undergraduate Indian dental students.

Materials And Methods: A modified questionnaire consisting of 24 items was distributed to 280 undergraduate dental students comprising males and females of different years at MNR Dental College, Sangareddy, India. Descriptive statistics and Chi-square/Fisher's exact tests were used for statistical analysis.

Evaluation of Effectiveness of Two Different Endodontic Retreatment Systems in Removal of Gutta-percha: An in vitro Study.

Aim: To determine the effectiveness of two different endodontic retreatment systems for the removal of laterally compacted gutta-percha (GP).

Materials And Methods: Sixty-three freshly extracted human maxillary central incisors were used for the study. The teeth were instrumented with K-flex files and obturated using lateral condensation technique with GP and AH Plus sealer.

Ramsay Hunt Syndrome: A Diagnostic Challenge for General Dental Practitioners.

Ramsay hunt syndrome is not just a syndrome but it's rather an infectious disease caused by reactivation of latent varicella-zoster virus in geniculate ganglion. This was first explained by J. Ramsay Hunt as a triad of complications like otalgia, mucosal and cutaneous rashes with or without trigeminal facial palsy.

Piezosurgery: A Boon for Modern Periodontics.

Dentistry has undergone significant advancement and has seen several changing concepts over a decade. One such novel innovation is piezosurgery. Piezoelectric bone surgery or otherwise known as piezosurgery is a novel technique invented by Professor Vercellotti in 1988 to overcome the limitations of traditional instrumentation in oral bone surgery by modifying and improving conventional ultrasound technology.

Clinical Utility of Serum Homocysteine and Folate as Tumor Markers in Oral Squamous Cell Carcinoma - A Cross-Sectional Study.

Introduction: Oral Squamous Cell Carcinoma (OSCC) is a common malignancy involving head and neck. Identifying the markers of molecular levels or biochemical markers involving the various metabolic reactions associated with the initiation and biological behavior of individual tumors are very important in diagnosis and prognosis.

Aim: To measure and compare the levels of serum Homocysteine (Hcy) and serum folate in OSCC patients, smoking group and healthy subjects and also to assess the clinical utility of serum Hcy as a potential tumor marker in OSCC.

Evaluation of dental and bone age in iron-deficient anemic children of South India.

Aims And Objectives: Dental and bone age is very essential for the dental practitioner in planning treatments and is an extra source of information for the pediatrician, orthopedician, and endocrinologist. There are few published data regarding collation between dental age, bone age, and chronological age in iron-deficiency anemic children. This study has been undertaken to evaluate and compare dental age, bone age, and chronological age in children with iron-deficiency anemia.

Computed tomography: Will the slices reveal the truth.

With the advances in the field of imaging sciences, new methods have been developed in dental radiology. These include digital radiography, density analyzing methods, cone beam computed tomography (CBCT), magnetic resonance imaging, ultrasound, and nuclear imaging techniques, which provide high-resolution detailed images of oral structures. The current review aims to critically elaborate the use of CBCT in endodontics.

Outcome of premolar extractions on Bolton's overall ratio and tooth size discrepancies in South India.

Aims And Objectives: Attainment of ideal occlusion is often restricted by disproportionate sizes of individual teeth, which is otherwise termed as tooth size discrepancy (TSD). While extraction of teeth for orthodontic purposes is not uncommon, there is considerable resistance against this school of thought. The extraction of premolars, in particular, received considerable attention because of the potential TSD that could result following the extraction of premolars.

Buccal Micronucleus Cytome Assay in Sickle Cell Disease.

Introduction: Sickle Cell Anaemia (SCA) is a commonly inherited blood disorder preceded by episodes of pain, chronic haemolytic anaemia and severe infections. The underlying phenomenon which causes this disease is the point mutation in the haemoglobin beta gene (Hbβ) found on chromosome 11 p. Increased oxidative stress leads to DNA damage.

Anaesthetic Efficacy of Topical Benzocaine Gel Combined with Hyaluronidase for Supplemental Intrapulpal Injection in Teeth with Irreversible Pulpitis- A Double Blinded Clinical Trial.

Objective: Intrapulpal injection technique is one of the most commonly employed method to achieve profound pulpal anaesthesia during an endodontic procedure. To determine if the topical application of benzocaine gel along with hyaluronidase to the pulp chamber could reduce the pain felt with the intrapulpal injection technique.

Materials And Methods: Two hundred patients with chronic irreversible pulpitis undergoing endodontic treatment for mandibular first molars in which the primary anaesthetic technique failed were selected and randomly divided into 2 groups.

Ameloblastic fibroma of the maxilla with bilateral presentation: report of a rare case with review of the literature.

Ameloblastic fibroma (AF) is an uncommon benign odontogenic tumour, with both epithelial and mesenchymal neoplastic proliferation. It occurs most frequently in the posterior region of the mandible, while its occurrence in the maxilla is extremely rare. They are usually encountered in children, emphasizing it as an important diagnostic consideration.

Osteochondroma of the palate: An interesting and an unusual case presentation.

A 40-year-old Indian male patient was referred to the Department of Oral and Maxillofacial Surgery with a slowly enlarging intra-oral, right-sided palatal swelling of one-year duration, with a previous diagnosis of osteochondroma. Extraorally, patient presented with a mild right-sided facial swelling. On intraoral examination, the palatal swelling was extending from the distal aspect of canine to the distal aspect of second molar with involvement of the maxillary tuberosity.