Biochemical failure rates in prostate cancer patients predicted to have biologically insignificant tumors treated with three-dimensional conformal radiation therapy.

Purpose: It has been suggested that patients with prostate cancer meeting the following criteria have pathologically determined potentially biologically insignificant (PBI) tumor and therefore should be considered for observation: clinical stage T1c, PSA density <0.1 ng/mL per gram, absence of Gleason pattern 4 or 5, three or fewer biopsy cores positive for tumor, and tumor involvement of no more than 50% of any core. We compared the biochemical control rates in men meeting the above criteria to those of all low-risk patients (clinical T1c, PSA View Article and Find Full Text PDF

Identification of environmental stress-regulated genes in Helicobacter pylori by a lacZ reporter gene fusion system.

Background: Helicobacter pylori persists in the human stomach for decades. This requires an efficient adaptation of H. pylori to the gastric niche and involves the regulation of bacterial genes in response to environmental stress.

Effect of surface treatment on fatigue behaviour between Tetric Ceram inlays and Variolink luting composite.

The effect of pre-treatment of composite inlays on bonding performance between a resin composite inlay and a luting composite has not been fully studied. The aim of the present study was to evaluate the influence of three different pre-treatment modes on fatigue bond strength and marginal adaptation. One hundred twenty resin composite discs (Tetric Ceram) were made as simulated inlays and randomly assigned to four groups (n=30): Without treatment (WT), hydrofluoric acid etching for 15 s + silanating (HF), roughening with a silicon carbide bur (SC), and silica coating + silanating (CO).

Adhesive luting of indirect restorations.

Purpose: To describe the potential of adhesive luting procedures with respect to (1) material characteristics and classifications, (2) film thickness, (3) overhang control, (4) bonding to different inlay materials, (5) adhesion to tooth substrates and the problem of hypersensitivities, (6) wear of luting composites, and (7) clinical performance.

Materials And Methods: A literature review of relevant studies of various in vitro and in vivo studies enables an overview of possibilities and limitations of adhesively luted indirect restorations.

Results: (1) Resin-based composites are the material of choice for adhesive luting.

Direct posterior composite restorations with a new adhesive system: one-year results.

Purpose: Syntac Sprint is a new one-bottle adhesive based on the total-etch and total-bond technique. The aim of this study was to compare the new restorative system consisting of Syntac Sprint and the resin composite Tetric Ceram with the clinically proven combination of the dentin adhesive Syntac Classic and the resin composite Tetric.

Materials And Methods: In a controlled prospective clinical study, 47 cavities (36 premolars, 11 molars; 29 maxillary, 17 mandibular; 6 occlusal, 33 occluso-approximal, 7 MOD, 1 > 3 surfaces) in 33 patients (17 female, 16 male) were filled.

Clinical performance and margin analysis of ariston pHc versus Solitaire I as posterior restorations after 1 year.

The resin composite Ariston pHc (pHc means pH control) was introduced as an alternative for fast amalgam replacement. The aim of the present study was to evaluate clinically the behaviour of this non-bonded resin composite material, promising the release of fluoride, calcium, and hydroxy ions, in comparison to a bonded resin composite (Solitaire I) in class I and II cavities. Ninety-nine cavities in 31 patients were restored in a controlled prospective clinical study.

Transcript-based computer animation of movement: evaluating a new tool for nonverbal behavior research.

A new approach for the use of computer animation in experimental nonverbal research is introduced. The method was evaluated in a pilot study comparing video recordings of movement in dyadic interactions with computer animations based on transcripts of the behavior, to determine whether similar impression effects could be obtained. At the core of our development is a software tool allowing for the conversion of so-called position time-series protocols of movement into animation scripts for a professional computer animation platform.

Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin.

Purpose: Although aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) exert inhibitory effects on platelets in vitro and in vivo, there are insufficient data to substantiate the use of NSAIDs alone as antiplatelet drugs in patients already taking aspirin. We therefore sought to determine whether aspirin, added to NSAID therapy, further suppresses platelet function.

Subjects And Methods: We enrolled 25 healthy adult volunteers who were administered ketoprofen (extended-release capsules, 200 mg daily) for 1 week, followed by ketoprofen (200 mg daily) and aspirin (325 mg daily) or ketoprofen (200 mg daily) alone during the second week.

Clinical performance of a condensable metal-reinforced glass ionomer cement in primary molars.

Objective: Aim of the present study was to evaluate the clinical suitability of the condensable metal-reinforced glass ionomer cement Hi-Dense in classes I and II cavities of primary molars.

Methods: Seventeen children received a total of fifty four Hi-Dense fillings (nineteen class I and thirty five class II). The restorations were clinically assessed at baseline, after one and after two years of clinical service according to modified USPHS codes and criteria.

Salmonella enterica serovar Typhi possesses a unique repertoire of fimbrial gene sequences.

Salmonella enterica serotype Typhi differs from nontyphoidal Salmonella serotypes by its strict host adaptation to humans and higher primates. Since fimbriae have been implicated in host adaptation, we investigated whether the serotype Typhi genome contains fimbrial operons which are unique to this pathogen or restricted to typhoidal Salmonella serotypes. This study established for the first time the total number of fimbrial operons present in an individual Salmonella serotype.

Leucite-reinforced glass ceramic inlays after six years: wear of luting composites.

Wear of luting composites is still an unsolved problem with adhesive inlays. However, only limited clinical research has been conducted regarding this phenomenon. This study evaluated the substance loss within the luting gap over a six-year period in vivo.

Leucite-reinforced glass ceramic inlays and onlays after six years: clinical behavior.

Ceramic inlays are an esthetic substitute for large amalgam and other metallic restorations. This controlled clinical study evaluated the performance of IPS Empress inlays and onlays with cuspal replacements and proximal margins below the cementoenamel junction over six years of clinical service. Six dentists placed 96 ceramic restorations in 34 patients.

Technique sensitivity of dentin bonding: effect of application mistakes on bond strength and marginal adaptation.

This in vitro study evaluated dentin bond strength and marginal adaptation of direct resin composites according to the manufacturers' instructions and with simulated application errors. One hundred and forty cavities were prepared into disks of freshly extracted human third molars and filled with one resin composite. Dentin adhesives of the third (with self-etching primer: Syntac Classic), fourth (with total etching: Scotchbond Multi-Purpose Plus) and fifth generation (one-bottle adhesive: Prime&Bond 2.

Repair strength of etched vs silica-coated metal-ceramic and all-ceramic restorations.

The purpose of this in vitro study was to examine shear bond strengths of composite resin to metal-exposed porcelain-fused-to-metal (PFM) and all-ceramic restorations after silica coating or etching with 5% hydrofluoric acid (HF). Specimens were fabricated for each of the following groups: two all-ceramic materials [a feldspathic porcelain (Vita Mark II) and a leucite-reinforced glass-ceramic (IPS Empress)], and one noble metal-ceramic (Orplid Keramik I alloy; Vita VMK 68 N felspathic veneer ceramic). These groups were repaired with resin composites after different pretreatment methods.

Dentin bond strength and marginal adaption after NaOCl pre-treatment.

The aim of this in vitro study was to compare the dentin bond strength and marginal adaptation of direct composite resins with and without additional NaOCl treatment after the etching process. A total of 150 cavities were prepared into disks of freshly extracted human third molars and filled with direct composite resins. Dentin adhesives of the fourth (with total etching: Scotchbond Multi-Purpose Plus, EBS, and Solid Bond), and fifth generation (one-bottle adhesives: Prime&Bond 2.

Long-term effect of dentin primers on enamel bond strength and marginal adaptation.

Contamination of etched enamel with dentin adhesive systems is unavoidable in clinical situations. The aim of this in vitro study was to evaluate the long-term effect of dentin adhesives and application technique on resin composite bond strength and marginal adaptation to enamel. Six hundred freshly extracted mandibular bovine incisors were used.

Simple predictors of uvulopalatopharyngoplasty outcome in the treatment of obstructive sleep apnea.

Study Objective: Our objective was to determine whether baseline polysomnography, cephalometry, and anthropometry data could predict uvulopalatopharyngoplasty (UPPP) success or failure.

Design: We retrospectively reviewed polysomnography, cephalometry, and anthropometry data from patients who underwent UPPP for obstructive sleep apnea (OSA).

Setting: A university medical center.

Giant cell myocarditis: most fatal of autoimmune diseases.

Objective: To increase awareness of giant cell myocarditis (GCM), its pathogenesis, and treatment.

Methods: Review of relevant publications from the English-language literature.

Results: GCM is a rare, frequently fatal inflammatory disorder of cardiac muscle of unknown origin, characterized by widespread degeneration and necrosis of myocardial fibers.

Rett syndrome: analysis of MECP2 and clinical characterization of 31 patients.

Unlabelled: Only recently have mutations in MECP2 been found to be a cause of Rett Syndrome (RTT), a neuro-developmental disorder characterized by mental retardation, loss of expressive speech, deceleration of head growth and loss of acquired skills that almost exclusively affects females. We analysed the MECP2 gene in 31 patients diagnosed with RTT. Sequencing of the coding region and the splice sites revealed mutations in 24 females (77.

Internal adaptation and overhang formation of direct Class II resin composite restorations.

The aim of the present in vitro study was to evaluate different restorative concepts for posterior resin composite fillings in terms of internal adaptation and overhang formation. Eighty standard occluso-distal cavities with and without a 1.5-mm bevel were restored in a phantom head using Syntac Classic and Tetric Ceram with and without Tetric Flow as thin lining or Solid Bond and Solitaire with and without FlowLine.

The shdA gene is restricted to serotypes of Salmonella enterica subspecies I and contributes to efficient and prolonged fecal shedding.

Little is known about factors which enable Salmonella serotypes to circulate within populations of livestock and domestic fowl. We have identified a DNA region which is present in Salmonella serotypes commonly isolated from livestock and domestic fowl (S. enterica subspecies I) but absent from reptile-associated Salmonella serotypes (S.

Why I would not recommend complementary or alternative therapies: a physician's perspective.

The use of complementary or alternative therapies by patients with rheumatic diseases is widespread and under-reported by patient to physician. The most commonly used forms of therapy are herbal/nutrient supplements, chiropractic, homeopathy, and acupuncture. The use of these therapies for treatment of rheumatic disease is not substantiated by review of the available medical literature.