Publications by authors named "Kragholm K"
Background: In patients with new-onset heart failure (HF), invasive coronary angiography (ICA) is recommended to rule out coronary artery disease (CAD).
Objective: To investigate the utility of a coronary artery calcium score (CACS) and coronary computed tomography angiography (CCTA) for rule-out of obstructive CAD in patients with new-onset HF.
Methods And Results: Patients with new-onset HF referred for cardiac computed tomography (CT) were included (2008-2022).
Background: Familial ST-depression Syndrome (Fam-STD) is a recently identified inherited cardiac disease characterized by a distinct electrocardiographic phenotype and occurrence of arrhythmias and heart failure.
Objective: We aimed to investigate the electrocardiographic prevalence of the Fam-STD and its association with cardiac events in a large, nationwide cohort.
Methods: We used a Danish nationwide ECG database containing 11,952,430 ECGs, from 2,485,987 unique individuals.
Purpose: To assess and describe chemotherapy-induced peripheral neuropathy (CIPN), a well-known complication to cancer treatment, using different methodologies in hematological patients.
Methods: Patients scheduled for treatment with vincristine, bortezomib, or lenalidomide were included in this longitudinal observational study. The patients were examined for CIPN before treatment (baseline), before each chemotherapy cycle, one month after end of treatment, and one year after baseline using patient-reported outcomes (Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Ntx-13 (FACT/GOG-Ntx-13)) and clinician-assessed outcomes (the Common Terminology Criteria for Adverse Events (CTCAE) and the Total Neuropathy Score-clinical version (TNSc©)).
Background: Ischemic heart disease (IHD) is the leading cause of mortality in the world with an increasing incidence. One of the interventions to treat IHD is coronary artery bypass grafting (CABG) and people with diabetes mellitus (DM) account for approximately one quarter of all patients who undergo coronary revascularization. Furthermore, people with DM have a higher risk of mortality due to heart failure (HF).
View Article and Find Full Text PDFMyocardial Infarction and All-Cause Mortality Following Percutaneous Coronary Intervention Versus Conservative Treatment of Chronic Total Occlusions: A West Denmark Heart Registry Study.
Catheter Cardiovasc Interv
February 2025
Background: Chronic coronary total occlusions (CTO) represent a therapeutic challenge, and results of randomized clinical trials and observational studies comparing conservative treatment versus percutaneous coronary intervention (PCI) are underpowered.
Aims: To assess myocardial infarction (MI) and all-cause mortality in consecutive patients with CTO lesions.
Methods: Using data from the West Denmark Heart Registry, patients with chronic coronary syndrome and a 100% occluded vessel by invasive coronary angiography (ICA) were identified.
Background: Incidence and prevalence of atrial fibrillation (AF) is increasing worldwide, and the condition is associated with high risk of adverse clinical outcomes. Increasing global migration results in more diverse patient populations, and knowledge about AF-related outcomes in immigrants is warranted.
Aim: To examine clinical outcomes after AF diagnosis across migrant populations in Denmark.
Objective: To evaluate the association between contemporary hormonal contraceptive use and the risk of incident ischaemic stroke and myocardial infarction.
Design: Real-world, nationwide, prospective cohort study.
Setting: Denmark, by use of national registries.
Background: Little is known about long-term outcomes beyond survival following acute aortic dissection. The aim of this research was to evaluate rates of home care initiation and nursing home admission during the first year after discharge and to assess factors associated with these needs.
Methods: All patients in Denmark with a first-time diagnosis of acute aortic dissection type A or B between 2006 and 2015 were identified using national registries.
Aims: The aim of this study was to describe the prognostic importance of left ventricular ejection fraction (LVEF) versus right ventricular (RV) dilatation and dysfunction in patients with heart failure (HF) from countries of different income levels.
Methods And Results: We enrolled 17 321 participants with HF from 40 countries. Participants were followed for a median (25th-75th percentile) of 2.
Article Synopsis
- The study aimed to determine if high levels of high-sensitivity troponin-T (hs-TnT) in patients with paroxysmal supraventricular tachycardia (PSVT) but no known cardiovascular disease increase the risk of death.
- Researchers reviewed data from 1,203 patients hospitalized from 2013 to 2020, finding that 65.8% had elevated hs-TnT levels.
- Results showed significantly higher short-term mortality (within 30 days) for patients with elevated hs-TnT, but long-term mortality (31-365 days) differences were not significant and may need further study.
Risk of cardiovascular disease (CVD) in patients with classical Hodgkin lymphoma (cHL) undergoing contemporary treatment is unclear. cHL patients ≥ 18 years at diagnosis treated with doxorubicin-containing chemotherapy between 2000 and 2022 were matched 1:5 with comparators on birth year, sex, and Charlson Comorbidity Index at time of matching (score of 0 or ≥ 1). Cause-specific cumulative incidence of a composite of CVDs with corresponding 95% confidence intervals (CIs) were computed with death and lymphoma relapse as competing events (i.
View Article and Find Full Text PDFThe risk of hyperkalemia in relation to different combinations of antihypertensive therapy remains to be elucidated. In this Danish register-based study, we aimed to investigate the risk of developing hyperkalemia in relation to different combinations of antihypertensive therapy. Using incidence density matching, we matched a hyperkalemic patient to five normokalemic patients on eGFR groups, age, sex, and time between study entry and date of potassium measurement.
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- Many COPD patients are diagnosed late, often during their first acute exacerbation (AECOPD), which increases mortality risk.
- In a study of over 107,000 patients, those diagnosed in primary care were younger, while those identified in hospitals were older, mostly male, and had more comorbidities.
- Hospital diagnoses were linked to higher one-year mortality rates compared to earlier diagnoses in primary care, emphasizing the importance of timely diagnosis.
Background: Chest pain is a frequent cause of health care contacts. We examined the prehospital management, in-hospital discharge diagnoses, and mortality of patients calling a non-emergency and emergency medical service with chest pain.
Methods: The Copenhagen Emergency Medical Services (EMS) consists of a non-emergency medical helpline (calls to 1813) and emergency medical service (1-1-2 calls).
Low-Dose Aspirin and Risk of Anaemia in Older Adults: Insights from a Danish Register-based Cohort Study.
Eur Heart J Qual Care Clin Outcomes
October 2024
Article Synopsis
- The study aimed to evaluate the risk of developing anemia in older Danish individuals (aged 65 and above) who used low-dose aspirin (LDA) for cardiovascular prevention between 2008 and 2013.
- Using Danish health registers, researchers tracked over 313,000 participants and found that LDA users had a significantly higher incidence of both hematinic deficiency (9.6%) and anemia (5.9%) compared to non-users.
- The results suggest that approximately 6 to 10 out of every 100 older adults using LDA may develop anemia within the first five years of treatment, highlighting the risks associated with LDA usage in this demographic.
Background: Ongoing opioid treatment can potentially modify symptoms of myocardial infarction (MI) and cause a lack of recognition and treatment delay.
Objectives: The purpose of this study was to examine MI symptoms and the time to hospitalization for patients in ongoing opioid treatment compared to patients without ongoing opioid treatment.
Methods: We evaluated calls to the Copenhagen Emergency Medical Services in Denmark from 2014 to 2018.
Long-term outcomes among out-of-hospital cardiac arrest survivors with reversible vs. non-reversible causes.
Eur Heart J Acute Cardiovasc Care
October 2024
Article Synopsis
- The study aimed to analyze long-term outcomes in survivors of out-of-hospital cardiac arrest (OHCA) based on the cause of the arrest, particularly focusing on reversible vs. non-reversible etiologies.
- Researchers examined data from the British Columbia Cardiac Arrest registry, categorizing patients by their OHCA cause and measuring outcomes like mortality and rehospitalization over three years.
- Results indicated that survivors with reversible ischemic causes had the best outcomes, while those with reversible non-ischemic causes experienced the worst outcomes, highlighting the importance of identifying the underlying cause of cardiac arrests.
Article Synopsis
- This study examined cardiovascular screening in patients with ANCA-associated vasculitis (AAV) and found higher rates of ECG abnormalities compared to matched controls.
- A total of 1431 AAV patients were analyzed, revealing a significant link between major ECG abnormalities and increased cardiovascular mortality risk.
- The findings suggest incorporating ECG assessments into regular care for AAV patients to better manage their cardiovascular health.
Article Synopsis
- Early percutaneous coronary intervention (PCI) is crucial for treating STEMI, yet the impact of delays in PCI timing has not been thoroughly evaluated.
- A study in Copenhagen analyzed the effects of delays caused by system factors or hospital distance on outcomes for STEMI patients, finding significant differences based on time from distress call to PCI.
- Results showed that delays over one hour substantially increased the risk of death, recurrent heart attacks, or heart failure, highlighting the importance of reducing the time from the first contact to PCI for better patient outcomes.
Background: The influence of age on cardiac troponin is unclear and may vary between cardiac troponin T (cTnT) and I (cTnI). We aimed to compare the impact of age on the diagnostic and prognostic utility of cTnT and cTnI.
Methods: This Danish nationwide, register-based cohort study included patients with at least one cardiac troponin (cTn) measurement from 2009 through June 2022, stratified into decades of age.
From illness to inactivity: Exploring the influence of physical diseases on youth Not in Education, Employment, or Training status in Europe: A systematic literature review.
J Adolesc
December 2024
Introduction: In 2010, 33% of young Europeans (ages 15-29) were Not in Education, Employment, or Training (NEET), rising to 40 million by 2015. Those with disabilities or health challenges are 40% more likely to be NEET. Hence, we conducted a systematic search to identify health challenges as NEET risk factors.
View Article and Find Full Text PDFBackground: Cardiac magnetic resonance imaging (cMRI) is considered the gold standard for the assessment of left ventricular (LV) systolic function. However, discrepancies have been reported in the literature between LV volumes assessed by transthoracic echocardiography (TTE) and cMRI. The objective of this study was to analyze the differences in LV volumes between different echocardiographic techniques and cMRI.
View Article and Find Full Text PDFObjectives: Call-takers face a complex situation when assessing medical problems in emergency medical services calls. Patients with myocardial infarction experiencing atypical symptoms risk misinterpretation. We examined development in call-takers' decision-making process in telephone consultations with patients having imminent myocardial infarction.
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