Publications by authors named "Kozue Tsurumi"
Article Synopsis
- This study analyzed the incidence of intestinal complications like stenosis and fistulas in patients with Crohn's disease (CD) at a Japanese hospital, finding that about 50% develop these issues within 5 years.
- The research involved 520 patients and looked at the cumulative rates of initial surgeries, revealing that about 50% of patients required surgery after 10 years.
- Identified risk factors for undergoing initial surgery included being a current smoker and having moderate to severe stenosis in various parts of the intestines, particularly in those with upper gastrointestinal disease at diagnosis.
Article Synopsis
- - Chromoendoscopy (CE) is less effective at identifying small gastric cancers (≤5 mm) on its own, making it challenging for accurate diagnosis.
- - A study compared CE to magnifying endoscopy with narrow band imaging (M-NBI) in terms of diagnostic performance, revealing M-NBI's sensitivity (78%) and specificity (92.9%) were significantly better than CE's (43.7% and 81.6%, respectively).
- - The findings suggest that M-NBI provides higher diagnostic accuracy and reproducibility for detecting minute gastric cancers compared to CE, highlighting its potential as a superior diagnostic tool.
Background And Aim: The aim of the present study was to endoscopically evaluate ileal mucosal healing during maintenance therapy with infliximab in order to investigate the clinical significance of endoscopic examination of ileal lesions in Crohn's disease patients.
Methods: This study retrospectively analyzed 54 patients who mainly had active ulcers of the ileum on endoscopy at baseline who were responsive to infliximab induction and who received infliximab maintenance therapy. Mucosal healing was defined as no ulcer or only ulcer scar.
Background And Aim: The prevalence of ulcerative colitis (UC) is increasing steadily in Japan. In Western countries, a bimodal distribution, with UC onset peaks in youth and middle age, is observed, and smoking cessation is reported as a risk factor for UC. However, there are few reports on a bimodal distribution of onset age among Japanese patients.
View Article and Find Full Text PDFBackground And Aim: The pharmacokinetics of tacrolimus (Tac) differ among individuals, and genetic polymorphisms of cytochrome P-450 (CYP) 3A4, CYP3A5, and ABCB1 are thought to be involved. The aim of this study was to clarify whether these genetic polymorphisms affect the pharmacokinetics of Tac in patients with ulcerative colitis.
Methods: The subjects in this study were 45 patients with moderate-to-severe ulcerative colitis who were resistant to other therapies and were treated with Tac.
Background/aims: In Japan, aphthous-type Crohn's disease (type A CD) is thought to represent an early phase of Crohn's disease (CD), and diagnosis of type A CD is possible in the diagnostic criteria for CD in Japan. However, the details of type A CD are not well understood.
Methods: Subjects comprised 649 CD patients diagnosed between 1985 and 2011.
Background And Aim: There have been very few reported investigations on the standardized incidence ratio (SIR) of intestinal cancer and all cancers other than intestinal cancer with Crohn's disease (CD) by organ in Japan. This study examined the risk of developing cancer (i.e.
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