Extended chains in vanadium O-centered complex [VOSeI]: synthesis and structure.

O-centered tetranuclear vanadium selenoiodide [VOSeI] (1) was synthesized by an ampoule method from the elements with addition of water. Its X-ray crystal structure (space group 2/, = 21.146(2) Å, = 5.

Immunogenicity and Efficacy of Combined mRNA Vaccine Against Influenza and SARS-CoV-2 in Mice Animal Models.

The combined or multivalent vaccines are actively used in pediatric practice and offer a series of advantages, including a reduced number of injections and visits to the doctor, simplicity of the vaccination schedule and minimization of side effects, easier vaccine monitoring and storage, and lower vaccination costs. The practice of widespread use of the combined vaccines has shown the potential to increase vaccination coverage against single infections. The mRNA platform has been shown to be effective against the COVID-19 pandemic and enables the development of combined vaccines.

Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response.

Seasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. Vaccination is generally accepted as the most effective strategy for influenza prevention. While current influenza vaccines are effective, they still have limitations, including narrow specificity for certain serological variants, which may result in a mismatch between vaccine antigens and circulating strains.

Major Role of S-Glycoprotein in Providing Immunogenicity and Protective Immunity in mRNA Lipid Nanoparticle Vaccines Based on SARS-CoV-2 Structural Proteins.

SARS-CoV-2 variants have evolved over time in recent years, demonstrating immune evasion of vaccine-induced neutralizing antibodies directed against the original S protein. Updated S-targeted vaccines provide a high level of protection against circulating variants of SARS-CoV-2, but this protection declines over time due to ongoing virus evolution. To achieve a broader protection, novel vaccine candidates involving additional antigens with low mutation rates are currently needed.

Alginate Gel Encapsulated with Enzybiotics Cocktail Is Effective against Multispecies Biofilms.

The development of new and effective antibacterials for pharmaceutical or cosmetic skin care that have a low potential for the emergence and expansion of bacterial resistance is of high demand in scientific and applied research. Great hopes are placed on alternative agents such as bactericidal peptidoglycan hydrolases, depolymerases, etc. Enzybiotic-based preparations are being studied for the treatment of various infections and, among others, can be used as topical formulations and dressings with protein-polysaccharide complexes.

Parental anxiety and pediatric vaccine refusal in a US national sample of parents.

Objectives: Understanding vaccine hesitancy among parents is of emerging interest and of rising importance for promoting vaccine uptake to prevent pediatric illness. Here, we examine associations between pediatric vaccine refusal and parental symptoms of anxiety.

Methods: Our cross-sectional survey assessed pediatric vaccine refusal in 1699 parents in a US national sample.

Evolution of the Electronic Structure of the -[ReSbipyCl] Octahedral Rhenium Cluster during Reduction.

Understanding the processes that occur during the redox transformations of complexes coordinated by redox-active apical ligands is important for the design of electrochemically active compounds with functional properties. In this work, a detailed analysis of the interaction energy and electronic structure was performed for cluster complexes -[ReSbipyCl] (n = 2-, 4-, 6-, 8-), which can be obtained by stepwise electrochemical reduction of a neutral cluster -[ReSbipyCl] in DMSO solution. It was shown that the formation of open-shell paramagnetic ions with S = 1, 2 and 1 is the most energetically favorable for n = 2-, 4- and 6-, respectively.

Prevalence of neurodevelopmental delays in infants with perinatal HIV infection in comparison with HIV exposure in rural South Africa.

Background: Assessing neurodevelopmental functioning in early infancy is essential as this is a critical period for infant development. Infants born to mothers with HIV are at a greater risk of developmental delays than those born to mothers without HIV. In this study, we analyzed differences in early neurodevelopmental functioning for infants with HIV exposure versus HIV infection to inform infant screening and early intervention.

Cells with stochastically increased methyltransferase to restriction endonuclease ratio provide an entry for bacteriophage into protected cell population.

The action of Type II restriction-modification (RM) systems depends on restriction endonuclease (REase), which cleaves foreign DNA at specific sites, and methyltransferase (MTase), which protects host genome from restriction by methylating the same sites. We here show that protection from phage infection increases as the copy number of plasmids carrying the Type II RM Esp1396I system is increased. However, since increased plasmid copy number leads to both increased absolute intracellular RM enzyme levels and to a decreased MTase/REase ratio, it is impossible to determine which factor determines resistance/susceptibility to infection.

The Role of Quadruple Bonding in the Electron Transport through a Dimolybdenum Tetraacetate Molecule.

A dimolybdenum tetraacetate (Mo(OCCH)) molecule is embedded between two electrodes formed by semi-infinite 1D monatomic chains of lithium, aluminum, and titanium atoms. Electron transport through the Mo(OCCH) molecule is calculated. The role of quadrupole bonding in the transport properties of the studied systems is analyzed.

Sputnik V Effectiveness against Hospitalization with COVID-19 during Omicron Dominance.

Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave of COVID-19 has been ongoing since the end of 2021. It is caused by a virus variant B.

Composite Polyvinylpyrrolidone-Sodium Alginate-Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications.

Today, the synthesis of biocompatible and bioresorbable composite materials such as "polymer matrix-mineral constituent," which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods.

Chirality and Relativistic Effects in Os(CO).

The energy and structural parameters were obtained for all forms of the carbonyl complex of osmium Os(CO) with D and D symmetries using density functional theory (DFT) methods. The calculations took into account various levels of relativistic effects, including those associated with nonconservation of spatial parity. It was shown that the ground state of Os(CO) corresponds to the D symmetry and thus may be characterized either as left-twisted (D) or right-twisted (D).

The {Re} Tetrahedral Cyanometalate Cluster Anion [{Re(μ-CCN)}(CN)] with Inner (μ-CCN) Ligands and Its Features in Coordination of Cu Cations.

A reaction between ReI and KCN at elevated temperature led to the formation of the new cyanometalate cluster anion [{Re(μ-CCN)}(CN)] (). The anion contains μ-CCN ligands, which are stabilized by the coordination to the triangular faces of the tetrahedral {Re} metallocluster in a μ mode. The compound crystallized as a potassium salt, and its crystal structure was determined by single-crystal X-ray diffraction analysis.

Effect of spin-phonon interactions on Urbach tails in flexible [M(bdc)(dabco)].

The optical properties of metal-organic frameworks [M(bdc)(dabco)] (M = Co, Ni, Cu, Zn) in the wavelength region of 300-1000 nm were studied, and the electronic band-to-band transitions were determined and characterized by the Kubelka-Munk approach and DFT calculations. Urbach edges for band-to-band transitions were determined. The effect of spin-phonon interactions on the width of Urbach edges in paramagnetic [M(bdc)(dabco)] is discussed.

Understanding structural flexibility of the paddle-wheel Zn-SBU motif in MOFs: influence of pillar ligands.

Structural parameters and energies of secondary building units (SBUs) in Zn2(C8H4O4)2·C6H12N2 have been examined with DFT and CCSD(T) methods. The SBU structure exhibits flexibility due to close energies of formation of its D4h, D4, and D2d forms. The potential energy surfaces (PESs) calculated for these systems testify that the presence of pillar ligands with negatively charged nitrogens (NCH or DABCO) can lead to almost barrier-free transitions between structural SBU forms.

PO and AsO: Pnictogenide Ligands in the Highly Charged Re Cluster Anions [{Re(PO)(PO)}(CN)], [{ReAs(AsO)}(CN)], and [{Re(AsO)}(CN)].

New tetrahedral anionic rhenium cluster complexes [{Re(PO)(PO)}(CN)] (1) and [{ReAs(AsO)}(CN)] (2) have been synthesized by the reaction of ReI with NaCN and P or KCN and As, respectively. Compound 2 was further oxidized by aqueous HO to produce the cluster anion [{Re(AsO)}(CN)] (3). The anions contain new pnictogen/oxygen-based ligands, PO and AsO, which were stabilized by the coordination to the triangular faces of the tetrahedral Re metallocluster in μ-mode.

Do ternary liquid mixtures exhibit negative main Fick diffusion coefficients?

Experimental data on Fick diffusion coefficients of ternary and higher mixtures depend on the reference frame; those which are in common use are associated with the average velocity either with respect to volume, mass or mole number. In this study, the dependence of diffusion coefficients on the reference frame is thoroughly analyzed for three ternary mixtures of different types. The first one, tetralin-isobutylbenzene-dodecane, can almost be considered as ideal, the second one, cyclohexane-toluene-methanol, exhibits liquid-liquid phase separation and the third one, water-ethanol-triethylene glycol, contains three associating species and is also strongly non-ideal.

Parity violating energy difference for mirror conformers of DABCO linker between two M cations (M = Zn, Cd, and Hg).

We have studied the potential energy surface of cations (M = Zn, Cd, and Hg), which are considered as a model for the DABCO linker in metal-organic frameworks, a new prospective class of materials. Relativistic four-component and two-component calculations of parity violating energy difference (PVED) for twisted isomers of cations have been performed. The right-twisted conformers of are more stable than the left-twisted ones.

From oxide to a new type of molecular tungsten compound: formation of bitetrahedral cluster complexes [{W(μ-O)(μ-CCN)}(CN)] and [{W(μ-O)(μ-As)}(CN)].

Tungsten trioxide has been found to be a convenient precursor for the synthesis of metal cluster compounds with new types of cluster cores. The reaction between WO3 and KCN led to the formation of the cluster complex [{W6(μ4-O)2(μ3-CCN)4}(CN)16]10-. Unexpectedly, it includes the fully deprotonated form of acetonitrile, the CCN3- anion, as a μ3-bridging ligand coordinated to the trigonal faces of the bitetrahedral W6 metallocluster.

Facile Substitution of Bridging SO Ligands in Re Bioctahedral Cluster Complexes.

Selective substitution of μ-SO groups by either O or Se ions occurs upon heating the bioctahedral rhenium cluster complex K[ReCS(μ-SO)(CN)] in air atmosphere or in the presence of a Se source, respectively, manifesting the remarkable lability of SO ligands bound to a transition-metal cluster. A series of compounds based on the new mixed-ligand anions, [ReCS(μ-O)(CN)], [ReCS(μ-Se)(CN)], and [ReCS(μ-O)(OH)], were isolated and their solid-state structures were elucidated by single-crystal X-ray diffraction analysis. Along with the previously reported μ-sulfide clusters, the new species constitute a series of rhenium anionic complexes with the common formula [ReCS(μ-Q)L] (Q = O, S, Se, L = CN; Q = O, S, L = OH), within which the total charge and number of cluster valence electrons (CVEs) are constant.

Thermal properties of Zn(CHO)•CHN metal-organic framework compound and mirror symmetry violation of dabco molecules.

Thermal properties of Zn(CHO)•CHN metal-organic framework compound at 8-300 K suggest the possibility of subbarrier tunnelling transitions between left-twisted (S) and right-twisted (R) forms of CHN dabco molecules with D point symmetry. The data agree with those obtained for the temperature behavior of nuclear spin-lattice relaxation times. It is shown that there is a temperature range where the transitions are stopped.

Activation Parameters of Self-Diffusion of Aromatic Chiral Molecules in External Magnetic Fields.

The mobility of aromatic chiral molecules 1-phenylethanol and 1-phenyl-1-propanol in liquids was studied by H NMR spectroscopy depending on the strength of the external magnetic field, temperature, and concentration ratio of enantiomers. The data obtained were analyzed using Arrhenius law. The activation parameters were found to depend on the applied field.