Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor.

Cell adhesion molecules (CAMs) are cell surface glycoproteins mediating interactions of cells with other cells and the extracellular matrix. By mediating the adhesion and modulating activity of other plasma membrane proteins, CAMs are involved in regulating a multitude of cellular processes, including growth, proliferation, migration, and survival of cells. In this review, we present evidence showing that various CAMs interact with the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase inducing pro-proliferative and anti-apoptotic intracellular signaling in response to binding to several soluble ligands, including the epidermal growth factor.

[Perioperative prevention of bleeding in glaucoma surgery].

Purpose: This study assesses the impact of preoperative administration of Oku-Oku eye drops on the severity of conjunctival hyperemia and the risk of hemorrhagic complications in the early postoperative period following glaucoma surgery.

Material And Methods: The study included a group of 30 patients (30 eyes) with uncontrolled primary open-angle glaucoma who underwent non-penetrating deep sclerectomy. The main group included 15 eyes, in which Oku-Oku drops were administered twice - on the day before surgery (upon hospital admission) and immediately before the operation.

[Thresholds and variability of retinal light sensitivity in each point of the examined visual field].

Purpose: This study assesses the light sensitivity and its variability in each point of the visual field in patients without glaucoma and with different stages of glaucoma.

Material And Methods: The data of a prospective analytical case-control study involving 500 patients were analyzed. The initial examination of all patients was performed using basic ophthalmological methods, including static perimetry.

Increasing the Hydration Activity of Tricalcium Silicate by Adding Microdispersed Ettringite as a Nucleating Agent.

Tricalcium silicate (CS) as a binder material has a decisive influence on the processes of hardening and strength gain of cements and concretes. One of the promising directions is the introduction of dispersed additives into cement mixtures, which allow micro-level control of the composition of hydration products and change the dynamics of the structure formation of cement stone. In this paper, the effect of a microdisperse ettringite additive on the kinetics of the hydration and hardening process of tricalcium silicate was studied.

Synthesis and Evaluation of Properties of an Additive Based on Bismuth Titanates for Cement Systems.

The development of modern building materials science involves the process of designing innovative materials that exhibit unique characteristics, such as energy efficiency, environmental friendliness, self-healing ability, and photocatalytic properties. This can be achieved by modifying cement with nano- and fine-dispersed additives that can give the material new properties. Such additives include a number of compounds based on the TiO-BiO system.

New Neutralizing Epitope Exposed on the Domain II of Tick-Borne Encephalitis Virus Envelope Glycoprotein E.

, formerly tick-borne encephalitis virus (TBEV), belongs to the genus. TBEV is transmitted by tick bites and infection with TBEV can lead to serious disorders of the central nervous system. In this study, a new protective monoclonal mouse antibody (mAb) FVN-32, with high binding activity to glycoprotein E of TBEV, was selected and examined in post exposure prophylaxis in a mouse model of TBEV infection.

[Modern achievements in the diagnosis and treatment of glaucoma].

Glaucoma is one of the most difficult and significant ocular conditions. The chronic asymptomatic course of glaucoma progression leads to irreversible deterioration of visual functions. Many aspects of its pathogenesis, the features of its clinical presentation, diagnosis and treatment have been identified in recent years.

The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes.

Tick-borne encephalitis virus (TBEV) is a flavivirus which causes an acute or sometimes chronic infection that frequently has severe neurological consequences, and is a major public health threat in Eurasia. TBEV is genetically classified into three distinct subtypes; however, at least one group of isolates, the Baikal subtype, also referred to as "886-84-like", challenges this classification. Baikal TBEV is a persistent group which has been repeatedly isolated from ticks and small mammals in the Buryat Republic, Irkutsk and Trans-Baikal regions of Russia for several decades.

Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival.

In the present study, we show that the inhibitor of the apoptosis-stimulating protein of p53 (iASPP) physically interacts with the hyaluronan receptor CD44 in normal and transformed cells. We noticed that the CD44 standard isoform (CD44s), but not the variant isoform (CD44v), bound to iASPP via the ankyrin-binding domain in CD44s. The formation of iASPP-CD44s complexes was promoted by hyaluronan stimulation in fibroblasts but not in epithelial cells.

[Comparative evaluation of hypotensive effectiveness of topical monotherapy and selective laser trabeculectomy].

Purpose: Comparison of the hypotensive effects of selective laser trabeculoplasty (SLT) and drug therapy in patients with newly diagnosed primary open-angle glaucoma (POAG) and ocular hypertension.

Material And Methods: Thirty patients (30 eyes) with newly diagnosed ophthalmic hypertension or POAG were observed. Patients of the 1st group (15 eyes) underwent standard SLT as a starting treatment, patients of the 2nd group (15 eyes) were prescribed monotherapy with a prostaglandin analog.

The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), also known as β-secretase, is an aspartic protease. The sorting of this enzyme into Rab11-positive recycling endosomes regulates the BACE1-mediated cleavage of its substrates, however, the mechanisms underlying this targeting remain poorly understood. The neural cell adhesion molecule 2 (NCAM2) is a substrate of BACE1.

Virio- and Bacterioplankton of the Coastal Water of the Moscow River.

The first study on the dynamics of virioplankton abundance (VA) in the coastal waters of the Moscow River in the autumn-winter period at stations differing in the level of anthropogenic impact has been performed. The VA in the waters of the more polluted Dzerzhinsky st. (with a mean of 235.

Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa.

The tick-borne flavivirus (TBFV) group contains at least 12 members where five of them are important pathogens of humans inducing diseases with varying severity (from mild fever forms to acute encephalitis). The taxonomy structure of TBFV is not fully clarified at present. In particular, there is a number of paraphyletic issues of tick-borne encephalitis virus (TBEV) and louping-ill virus (LIV).

[Coefficient of biomechanical stress in assessment of the degree of intraocular pressure compensation].

Unlabelled: Intraocular pressure is the one modifiable factor, which correct assessment and normalization initiates the treatment of glaucoma. The accuracy of its measurement by traditional methods depends on biomechanical properties of the fibrous tunic of the eye, which in modern clinical practice are most successfully studied by the method of bidirectional applanation of the cornea using the Ocular Response Analyzer (ORA). Mathematical integration of the parameters it measures makes it possible to calculate the coefficient of biomechanical stress (K) that characterizes changes in the fibrous tunic of the eye induced by intraocular pressure, and serves as a criterion for intraocular pressure compensation.

[Osteosarcopenia in chronic pancreatitis].

Aim: To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP).

Materials And Methods: A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 patients with CP included, the control group 30 healthy individuals.

A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.

Background & Aims: Golexanolone is a novel small molecule GABA-A receptor-modulating steroid antagonist under development for the treatment of cognitive and vigilance disorders caused by allosteric over-activation of GABA-A receptors by neurosteroids. It restored spatial learning and motor coordination in animal models of hepatic encephalopathy (HE) and mitigated the effects of intravenous allopregnanolone in healthy adults in a dose-dependent fashion. Herein, we report data on the safety, pharmacokinetics (PK) and efficacy of golexanolone in adult patients with cirrhosis.

Isolated From Third-Generation Laboratory Colony Ticks.

are vertically-transmitted endosymbionts of ticks and other arthropods. Field-collected have been reported to harbour , but nothing is known about their persistence during laboratory colonisation of this tick species. We successfully isolated from internal organs of 6/10 unfed adult ticks, belonging to the third generation of an laboratory colony, into tick cell culture.

Cell Adhesion Molecules and Protein Synthesis Regulation in Neurons.

Cell adhesion molecules (CAMs) mediate interactions of neurons with the extracellular environment by forming adhesive bonds with CAMs on adjacent membranes or binding to proteins of the extracellular matrix. Binding of CAMs to their extracellular ligands results in the activation of intracellular signaling cascades, leading to changes in neuronal structure and the molecular composition and function of neuronal contacts. Ultimately, many of these changes depend on the synthesis of new proteins.

[Thermography of ocular surface tissues in the assessment of aseptic postoperative inflammation].

Purpose: To determine the thermographic parameters of ocular surface tissues in various types of anti-glaucoma operations.

Material And Methods: The study included 70 patients with glaucoma (140 eyes) and 28 patients (56 eyes) with cataract and planned phacoemulsification. All patients underwent dynamic infrared thermography of the eye surface to evaluate the aseptic inflammatory response before and after surgery.

[Chronic pancreatitis with IBS-like syndrome: approach to therapy].

Aim: To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.

Materials And Methods: 312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27.

Alzheimer's Disease and Parkinson Dementia Distinguished by Cognitive Marker.

Background: Temporary memory binding (TMB) has been shown to be specifically affected by Alzheimer's disease (AD) when it is assessed via free recall and titrating the task demands to equate baseline performance across patients.

Methods: Patients with Parkinson's disease (PD) were subdivided into patients with and without cognitive impairment and compared with AD and amnestic mild cognitive impairment (aMCI) patients on their performance on the TMB.

Results: The results show that only patients with AD dementia present with impaired TMB performance.

Genetic diversity and geographical distribution of the Siberian subtype of the tick-borne encephalitis virus.

The tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is currently subdivided into three main subtypes-the European (TBEV-Eu), the Far-Eastern (TBEV-FE), and the Siberian (TBEV-Sib). The TBEV-Sib is the most common subtype and found in all regions where TBEV was detected, except for Central and Western Europe. Currently, four genetic lineages have been described within TBEV-Sib.

[Frequency and type of macular edema after cataract surgery in patients with glaucoma].

Cataract is one of the common causes of reversible vision loss in people older than 50 years. Currently, the only way to treat it effectively is phacoemulsification with simultaneous implantation of an intraocular lens - a method that minimizes the amount of surgical trauma and the number of intra- and postoperative complications. Nevertheless, the problem of prevention and timely diagnosis of pathological changes in the retina, which may develop after extraction of cataracts, and in particular - macular edema, remains relevant.