Effect of the aggregation state of amyloid-beta (25-35) on the brain oxidative stress in vivo.

Aggregation pathway of amyloid-β (25-35) in water affects the oxidative stress in the brain observed after administration of aggregated peptide in animals in vivo. Our studies on peptide aggregation ex situ prior to injection suggest that from the onset of peptide incubation in aqueous media, all samples exhibit the formation of fibril-like aggregates, characterized by a significant amount of β-sheets. This induces significant oxidative stress in vivo as observed for up to 60 min of peptide aggregation time.

Trust in government moderates the association between fear of COVID-19 as well as empathic concern and preventive behaviour.

With the COVID-19 pandemic, behavioural scientists aimed to illuminate reasons why people comply with (or not) large-scale cooperative activities. Here we investigated the motives that underlie support for COVID-19 preventive behaviours in a sample of 12,758 individuals from 34 countries. We hypothesized that the associations of empathic prosocial concern and fear of disease with support towards preventive COVID-19 behaviours would be moderated by trust in the government.

Anxiety in a COVID-19 school year context: three-way longitudinal study on Slovenian adolescent sample.

Background And Objectives: We investigated the trajectories of anxiety, general anxiety and more specifically COVID-19 anxiety in the period of school closure in Slovenia using a longitudinal design with three time points: at the beginning, in the middle and at the end of the school year.

Design And Methods: We have used data from a representative adolescent sample for Slovenia ( = 1233) and two anxiety scales: the LAOM Anxiety Scale and the COVID-19 Anxiety Scale. The findings from latent growth curve models show a significant difference in initial levels and a decrease in both types of anxiety as well as an interaction effect between the initial level and the rate of change of COVID-19 anxiety.

The Coronavirus Anxiety Scale: Cross-national measurement invariance and convergent validity evidence.

Coronavirus Anxiety Scale (CAS) is a widely used measure that captures somatic symptoms of coronavirus-related anxiety. In a large-scale collaboration spanning 60 countries ( = 21,513), we examined the CAS's measurement invariance and assessed the convergent validity of CAS scores in relation to the fear of COVID-19 (FCV-19S) and the satisfaction with life (SWLS-3) scales. We utilized both conventional exact invariance tests and alignment procedures, with results revealing that the single-factor model fit the data well in almost all countries.

A case of Joubert syndrome caused by novel compound heterozygous variants in the gene.

Joubert syndrome (JS) is a recessive disorder that is characterized by midbrain-hindbrain malformation and shows the "molar tooth sign" on magnetic resonance imaging. Mutations in 40 genes, including Abelson helper integration site 1 (), inositol polyphosphate-5-phosphatase (), coiled-coil and c2 domain-containing protein 2A (), and ARL2-like protein 1 (), can cause JS. Classic JS is a part of a group of diseases associated with JS, and its manifestations include various neurological signs such as skeletal abnormalities, ocular coloboma, renal disease, and hepatic fibrosis.

Anxiety and COVID-19 Anxiety in Positive Youth Development: A Latent Profile Analysis Study.

The COVID-19 pandemic has accelerated anxiety and triggered a new and specific COVID-19 anxiety in all age groups, especially in adolescence. The aim of the present study was to identify differences between anxiety and COVID-19 anxiety in profiles of positive outcomes by using the Positive Youth Development (PYD) framework (i.e.

The development of the 5Cs of positive youth development in a school year: A 3-wave longitudinal study of Slovenian youth during the COVID-19 pandemic.

The paper analyses the longitudinal pathways for the 5Cs of positive youth development outcomes (Competence, Confidence, Character, Caring, Connection) in a school context during the COVID-19 pandemic. The theoretical framework for the paper is provided by the Positive youth development (PYD) perspective, which focuses on the importance of the interplay between individual characteristics and contexts. In the period of adolescence, school and its characteristics are one of the most influential contexts for the promotion of positive youth development.

Novel mutation in the gene causes early-onset but slow-progressive Charcot-Marie-Tooth disease in a Russian family: a case report.

Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous group of peripheral neuropathies most of which are associated with mutations in four genes including peripheral myelin protein-22 (, myelin protein zero (), gap junction protein beta1 () and mitofusin2 (). This current case report describes the clinical and genetic characteristics of a 6-year-old male proband. A physical examination revealed muscular hypotonia.

Self-assembly in binary mixtures of spherical colloids.

Colloidal suspensions of monodisperse spherical particles have been extensively studied since one of the main advantages of these systems is their similarity to atomic ones. This property has been used successfully in basic science to understand the equilibrium and non-equilibrium behavior of model colloids and to correlate them with their atomic counterparts. In contrast, suspensions used in technological processes are usually more complex.

Optimization of rifampicin encapsulation in PLGA polymeric reservoirs.

Rifampicin is one of the most commonly used antibiotics for treating tuberculosis, but shows low bioavailability and requires long-term administration, and hence its use may result in severe side effects. Encapsulation of rifampicin in polymeric reservoirs allows it to be administered locally and improves its pharmacological action. High rifampicin loading is crucial for obtaining an adequate therapeutic effect.

The psychological response and perception of stress during the COVID-19 pandemic in Slovenia: Three-wave repeated cross-sectional study.

In addition to COVID-19 being a health threat, its longevity and restrictions act as significant stressors and risk for mental health. In the current study, we take a look at how psychological response, both its positive aspects, for example, mental well-being and life satisfaction, and its negative aspects, for example, anxiety and COVID-19 anxiety, have changed as the pandemic has continued (first three waves in Slovenia). Additionally, we are interested in whether the psychological response is associated with the perception of stress level in waves 2 and 3 as less, equally or more stressful when compared to the stress level in wave 1 and what shapes these perceptions.

External Developmental Assets and Positive Identity Among Emerging Adults in Norway, Romania, Slovenia, and Turkey.

The present study adopts The Developmental Assets and Positive Youth Development (PYD) perspectives which (in contrast to the deficit-based approaches which highlight risks and deficit in youth development) claim that young people have potencies to achieve optimal development if supported by their social environment. Extant research indicates that developmental assets are linked with a variety of thriving indicators. The present research aimed to contribute to the PYD research by examining the external developmental assets (support, empowerment, and boundaries and expectations) emerging adults ( = 2055; age range = 18-28) perceived in their social environment and the level of their positive identity in four countries (Norway, Romania, Slovenia and Turkey), which have different rankings in economic, human, and youth development indices.

The Association Between the 5Cs and Anxiety-Insights From Three Countries: Portugal, Slovenia, and Spain.

Several of the most frequent psychological difficulties in childhood and adolescence are related to anxiety and lead to numerous short- and long-term negative outcomes in emotional, social, and academic domains. Empirical evidence consistently shows that the 5Cs (competence, caring, confidence, connection, and character) of Positive Youth Development (PYD) are positively related to adolescents' contribution to self, family, and society as well as negatively related to risky behaviors and emotional difficulties, such as anxiety. Thus, the PYD can be one of the models that informs prevention programs.

Ultrasound-assisted production and optimization of mini-emulsions in a microfluidic chip in continuous-flow.

The use of ultrasound to generate mini-emulsions (50 nm to 1 μm in diameter) and nanoemulsions (mean droplet diameter < 200 nm) is of great relevance in drug delivery, particle synthesis and cosmetic and food industries. Therefore, it is desirable to develop new strategies to obtain new formulations faster and with less reagent consumption. Here, we present a polydimethylsiloxane (PDMS)-based microfluidic device that generates oil-in-water or water-in-oil mini-emulsions in continuous flow employing ultrasound as the driving force.

Gelation of amphiphilic janus particles in an apolar medium.

Hypothesis: The anisotropic nature of colloidal particles results in orientation-dependent interactions that organize the particles into peculiar structures different from those formed by isotropic colloids. Particles with a hydrophilic hemisphere are expected to assemble in hydrophobic solvents due to the contribution of hydrophobic interactions as observed for molecular amphiphiles.

Experiments: Asymmetrically decorated silica-based Janus particles are dispersed in an apolar solvent, chloroform, and their structure and dynamics are studied by light scattering and compared with computer simulations.

Two novel PCDH19 mutations in Russian patients with epilepsy with intellectual disability limited to females: a case report.

Background: Epilepsy with intellectual disability limited to females (Epileptic encephalopathy, early infantile, 9; EIEE9) is a rare early infantile epileptic encephalopathy characterized by an unusual X-linked inheritance: females with heterozygous mutations are affected, while hemizygous males are not.

Case Presentation: We describe the clinical and molecular characteristics of 2 Russian patients with EIEE9 (females, ages 3 years and 7 years). In these patients seizures developed at the age of 3 years.

Gallic acid improves recognition memory and decreases oxidative-inflammatory damage in the rat hippocampus with metabolic syndrome.

Metabolic syndrome (MS) results from excessive consumption of high-calorie foods and sedentary lifestyles. Clinically, insulin resistance, abdominal obesity, hyperglycemia, dyslipidemia, and hypertension are observed. MS has been considered a risk factor in the development of dementia.

Neuronal ceroid lipofuscinosis in the Russian population: Two novel mutations and the prevalence of heterozygous carriers.

Background: Neuronal ceroid lipofuscinoses (NCLs) are a group of neurodegenerative disorders characterized by an accumulation of lipofuscin in the body's tissues. NCLs are associated with variable age of onset and progressive symptoms including seizures, psychomotor decline, and loss of vision.

Methods: We describe the clinical and molecular characteristics of four Russian patients with NCL (one female and three males, with ages ranging from 4 to 5 years).

Equilibrium clustering of colloidal particles at an oil/water interface due to competing long-range interactions.

Hypothesis: Colloids at fluid interfaces organize according to inter-particle interactions. The main contributions to an effective interaction potential are expected to be electrostatic dipole-dipole repulsion and capillary attraction due to fluid interface deformation. When these interactions are weak, a secondary minimum in the particle pair interaction potential is expected.

Liddle syndrome due to a novel mutation in the γ subunit of the epithelial sodium channel (ENaC) in family from Russia: a case report.

Background: Liddle syndrome is a monogenic disease with autosomal dominant inheritance. Basic characteristics of this disease are hypertension, reduced concentration of aldosterone and renin activity, as well as increased excretion of potassium leading to low level of potassium in serum and metabolic alkalosis. The cause of Liddle syndrome is missense or frameshift mutations in SCNN1A, SCNN1B, or SCNN1G genes that encode epithelial sodium channel subunits.

Structural Changes in Wormlike Micelles on the Incorporation of Small Photoswitchable Molecules.

Chromophores susceptible to light-induced trans-cis isomerization embedded in cylindrical micelles can modify micelles and their light-responsive performance. A small chromophore (4-(phenylazo)benzoate ion) is embedded in cylindrical micelles made of cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal) in water. The microstructure is examined by scanning electron microscopy (SEM) and nuclear magnetic resonance (NMR).

A novel elastin gene frameshift mutation in a Russian family with cutis laxa: a case report.

Background: Cutis laxa (CL) is a rare connective tissue disorder characterized by loose, redundant, inelastic and wrinkled skin. Patients develop a prematurely aged appearance. Inheritance can be autosomal dominant or autosomal recessive.

School-based prevention of anxiety using the "My FRIENDS" emotional resilience program: Six-month follow-up.

Anxiety-related problems are common in childhood and adolescence and, if left untreated, may hold short-term and long-term negative consequences for psychosocial functioning and other domains. In addition to having negative individual-level consequences, anxiety-related problems may have a negative impact at the school level. Because almost all children and adolescents attend school, school plays a significant role in development as a socialisation agent and provides an ideal venue for the delivery of prevention and intervention programs.

A novel MFSD8 mutation in a Russian patient with neuronal ceroid lipofuscinosis type 7: a case report.

Background: Neuronal ceroid lipofuscinoses (NCLs) are the most common autosomal recessive neurodegenerative disorders in children. Clinical manifestations include progressive cognitive decline, motor impairment, ataxia, visual loss, seizures and early death. To date more than 440 NCL-causing mutations in 13 genes are known.

Bilayers of Janus and homogeneous particle mixtures trapped at an air/water interface.

We study mixtures of amphiphilic Janus and homogeneous hydrophobic particles trapped at an air/water interface. In contrast to an expected monolayer formation, bilayers of colloidal particles are produced. Despite their strong interfacial adsorption, Janus particles form the upper layer.